Alzheimer's and the dysfunctional mitochondria

Alzheimer's Mitochondria Hypothesis: Mitochondrias must function and move or amyloid appears. Alzheimer's is not autoimmune.

Estrogen reduces amyloid
http://www.ncbi.nlm.nih.gov/pubmed/9546791

Lower brain estrogen increases amyloid
http://www.pnas.org/content/102/52/19198

Estrogen Beta receptor and alzheimer's
http://www.ncbi.nlm.nih.gov/pubmed/26307455
http://www.ncbi.nlm.nih.gov/pubmed/24096044
http://www.ncbi.nlm.nih.gov/pubmed/23948892
http://www.ncbi.nlm.nih.gov/pubmed/22840752

Memory impairment in estrogen receptor knockout mice
http://link.springer.com/article/10.1007%2Fs12035-014-8853-z

The beta estrogen receptor of nerves cycles to the mitochondria: improves function
http://www.ncbi.nlm.nih.gov/pubmed/26301952
http://www.ncbi.nlm.nih.gov/pubmed/22840752



Amyloid reflects the function of the mitochondria: this genetic defect causes amyloid.
http://www.ncbi.nlm.nih.gov/pubmed/19018796

Diacetyl, mitochondria, and amyloid
http://www.ncbi.nlm.nih.gov/pubmed/22731744
http://www.ncbi.nlm.nih.gov/pubmed/21131528

Popcorn diacetyl and bronchiolitits obliterans....are amyloids there?  "amyloid in popcorn lung"
http://www.ncbi.nlm.nih.gov/pubmed/12151470
http://www.ncbi.nlm.nih.gov/pubmed/17541015
http://www.ncbi.nlm.nih.gov/pubmed/17464280
http://www.ncbi.nlm.nih.gov/pubmed/18772104
 http://www.livescience.com/22308-new-microwave-popcorn-chemical-linked-to-lung-damage.html

Herpes destroys host's mitochondrial DNA
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1796774/

the herpes virus drives the mitochondria down the nerve root to other nerves!
http://www.sciencedirect.com/science/article/pii/S1931312812001047 
herpes causes amyloid
http://www.ncbi.nlm.nih.gov/pubmed/17980964
http://www.ncbi.nlm.nih.gov/pubmed/16109164

 Herpes and Alzheimer's Patients
http://www.ncbi.nlm.nih.gov/pubmed/18973185
http://www.ncbi.nlm.nih.gov/pubmed/22216291
http://www.ncbi.nlm.nih.gov/pubmed/18982063
http://www.ncbi.nlm.nih.gov/pubmed/23261465 

Note that the herpes viruses may use estrogen beta receptors to get into the mitochondria.
reactivation of herpes virus is linked to the estrogen receptor
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2798450/

Imagine the herpes virus traveling down the nerve to the next one in little mitochondrial cars and breaking them as they go.

Mothers of kids with down syndrome and risk of alzheimer's (faulty mitochondria through age?)
http://www.ncbi.nlm.nih.gov/pubmed/7914304

Mothers give a grab bag of mitochondrias to their children. "the good, the bad, and the ugly" mitochondrias are randomly given to offspring. Sometimes more bad then good.  A mother can develop Alzheimer's sooner but it depends on how many dysfunctional mitochondria she has.

Amyloidosis is the high with Agent orange patients
http://www.ncbi.nlm.nih.gov/pubmed/24906069

Auxins (agent orange chemicals) bind the mitochondria directly causing dysfunction
http://www.ncbi.nlm.nih.gov/pubmed/11566291

The Amyloid show up in the legs where people had been exposed to the chemical auxin and further supports the notion that when mitochondrias are broken that amyloid results.

Papers suggesting that amyloid and mitochondria connections
http://www.ncbi.nlm.nih.gov/pubmed/22833458
http://www.jneurosci.org/content/33/43/17042.short

Previous papers discussing Alzheimer's and mitochondrial dysfunction
http://www.sciencedirect.com/science/article/pii/S0925443909002427
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907118/
http://www.ncbi.nlm.nih.gov/pubmed/15193340
there are tons more but it is unclear why the mitochondria has issues

APP function...why does amyloid build up?
http://www.ncbi.nlm.nih.gov/pubmed/26274614

I had suggested that it was a serine protease growth key, a necessary function
http://angelabiggs.blogspot.com/2014/03/rescued-app-paper-from-alzforum-written.html
I need to figure out the date i wrote this for the forum.

APP triggering growth of colon cells
http://www.ncbi.nlm.nih.gov/pubmed/11279603

sAPP and neurite extentions
http://www.ncbi.nlm.nih.gov/pubmed/8083748
http://www.ncbi.nlm.nih.gov/pubmed/9110259

APP as a serine protease and neuroserpin?
http://www.ncbi.nlm.nih.gov/pubmed/16849336
http://www.ncbi.nlm.nih.gov/pubmed/19843463

Nitric oxide stops mitochondria of firefly
http://icb.oxfordjournals.org/content/44/3/213.long

NO and brain mitochondria
http://www.nature.com/nrm/journal/v3/n3/abs/nrm762.html

Now imagine in an active neuron the mitochondria car is moving quickly down the microtubular tracks to the synapse...NO would normally halt the movement. If the mitochondrias had not reached their destination would the synapse send an app signal in an attempt to keep the mitochondrias moving?

Amyloid-beta inhibits NO formation
http://www.jneurosci.org/content/25/29/6887.full
 Is amyloid-beta  the growth switch clipped because it is not working?

But if nitric oxide was not the reason the mitochondria wasn't moving....would amyloid-beta continue to be made and sent in desperation by the synapse? If herpes viruses were destroying the mitochondria would NO be low because of amyloid-beta?

Anti-herpes virus stuff
Arginine  http://www.ncbi.nlm.nih.gov/pubmed/19288025
Vit C, ascorbic acid: http://www.ncbi.nlm.nih.gov/pubmed/18813862
Lemon balm: http://www.ncbi.nlm.nih.gov/pubmed/18693101

Lemon balm and alz memory?
http://www.ncbi.nlm.nih.gov/pubmed/12888775