Thursday, February 15, 2018

TLR4 of the Fibroblast vs. Epithelial

Looking at the non immune cells with TLR4

Fibroblasts connective tissue have TLR4 that when triggered creates il-12 which stimulates TH1 and low amounts of IFNgamma which trigger MHC2 expression of Bcells

Epithelial cells (skin) have TLR4 that when triggered creates il-18 that inc IFNgamma which stimulates NK cells

Now looking at areas of the body:

Uterus
thin epithelial coumn
thick connective tissue area
HIGH il-12
Chlamydia

Lung
25% connective tissue
75% epithelial tissue
HIGH il-18
Mycoplasma (ER infection)

Intestine
mucosal epithelium
lamina propria (loose connective tissue)
are they equal amounts?


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