Saturday, February 17, 2018

il-19 is a mitochondrial pore, il-26 is a nuclear pore, so is il-22 a pore too but against vacuoles?

The long chains of the il-20 family:
il-19
il-22
il-26
il-24

il-26 a cytokine that forms a nuclear pore when bound by DNA
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919036/
il-19 expressed under these conditions:

1. changing the membrane potential of developing Thelper cells so that they become TH2 cells
2. to pop mitochondria's with viral infections under TH17 conditions

il-19 and TH2 cytokines
https://www.ncbi.nlm.nih.gov/pubmed/28597022

oxphos and TH1-TH2
https://books.google.com/books?id=R4HMK8uI4NIC&pg=PA640&lpg=PA640&dq=th2+mitochondria&source=bl&ots=YelNp0eV-x&sig=RWKWffoKznEwcI7brFkBHdewt2A&hl=en&sa=X&ved=0ahUKEwjj_a3Cj67ZAhVX0mMKHRidAAoQ6AEIbDAI#v=onepage&q=th2%20mitochondria&f=false

il-19 increases macrophage polarization (m2)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447484/

some how leaking protons increases ox phos?

il-17a and il-4 synergism to increase il-19
http://www.jacionline.org/article/S0091-6749(08)00759-8/pdf

il-19 and TNF alpha
https://www.ncbi.nlm.nih.gov/pubmed/22103848


Is il-22 a pore too but against vacuoles?

il-22 inhibited autophagy
http://www.ijbs.com/v08p0249.htm

autophagy is required for hyper mucus production
https://www.ncbi.nlm.nih.gov/pubmed/26671423
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044763/

il-17 increases mucus
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006454/

autophagic vacuoles arise for mucus
https://www.ncbi.nlm.nih.gov/pubmed/1324248

Does il-17 and il-22 have opposite purposes? Does il-22 pop the vacuoles involved with mucus autophagy?  Does il-22 the vacuoles with bacterias in them?

il-22 and acetaminophen: longer exposure is damaging
https://www.ncbi.nlm.nih.gov/pubmed/25063867

autophagy protects against acetaminophen induced liver damage
https://www.ncbi.nlm.nih.gov/pubmed/21932416












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