The functionality of cytokines becomes obvious when they are organized into groups.
Type one cytokines work primarily at the Hematopoiesis and these can be divided into 3 groups:
Cytokines using beta chains, cytokines using gamma chains, and the GP130 cytokines.
The development from myeloid progenitor cells involves the beta chain cytokines;
the development from lymphoid progenitor cells involves the gamma chain cytokines;
and the GP130 cytokines are powerful regulators. GP130 cytokines control neutrophils,
macrophages, natural killer cells, the "on switches or launch codes" for B cell development il-4 and
il-12, and the "on switch " for either Treg or TH17 cells.
cytokine receptor family review
http://www.sinobiological.com/Cytokine-Families-Cytokine-Family-a-5797.html
The GP130 Family: il-6, il-11, and TGF-beta
il-6 monocytes to macrophages
https://www.ncbi.nlm.nih.gov/pubmed/10848814
il-6 controls il-4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196041/
il-11 stops the macrophages from producing il-12
https://www.ncbi.nlm.nih.gov/pubmed/11940481
il-11 and Nk development
https://www.ncbi.nlm.nih.gov/pubmed/15499555
TGF beta and TH17
https://link.springer.com/chapter/10.1007/978-1-4419-9371-7_3
(TH17 can be started by il-6 or TGF-beta1 but it is my hypothesis that different cytokines result )
GP130
https://en.wikipedia.org/wiki/Glycoprotein_130
il-10 is the stop cytokine
il-10 stops pg130 cytokines (neutrophils macrophages and NKs)
il-10 stops T FH cells from secreting il-4 and il-21 which stops the GC from producing B cells
il-10 and gp130
https://www.ncbi.nlm.nih.gov/pubmed/22140267
Cytokines using Beta chains: il-3, il-5, GM-CSF are all on the myeloid side
Cytokines using Gamma chains: il-2, il-7, il-15, il-21, il-4, il-9 are all on the lymphoid side
The il-1 family cytokines and Chemokines
When an infection occurs the first cytokine made by macrophages and monocytes is the il-1 family cytokines.
il-1 family cytokines trigger cells to cytokine rain. This produces massive amounts of chemokines.
il-1 induces fibroblasts to produce chemokines which are attractant proteins.
il-1 also induces the expression of adhesion proteins so the arriving immune system knows where to stick.
The IFN family cytokines
These cytokines identify where inside the host cell the virus is hiding and coordinates the immune response attack. Which HLA to express and which TAM hands to wear.
Type one cytokines work primarily at the Hematopoiesis and these can be divided into 3 groups:
Cytokines using beta chains, cytokines using gamma chains, and the GP130 cytokines.
The development from myeloid progenitor cells involves the beta chain cytokines;
the development from lymphoid progenitor cells involves the gamma chain cytokines;
and the GP130 cytokines are powerful regulators. GP130 cytokines control neutrophils,
macrophages, natural killer cells, the "on switches or launch codes" for B cell development il-4 and
il-12, and the "on switch " for either Treg or TH17 cells.
cytokine receptor family review
http://www.sinobiological.com/Cytokine-Families-Cytokine-Family-a-5797.html
il-6 monocytes to macrophages
https://www.ncbi.nlm.nih.gov/pubmed/10848814
il-6 controls il-4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2196041/
il-11 stops the macrophages from producing il-12
https://www.ncbi.nlm.nih.gov/pubmed/11940481
il-11 and Nk development
https://www.ncbi.nlm.nih.gov/pubmed/15499555
TGF beta and TH17
https://link.springer.com/chapter/10.1007/978-1-4419-9371-7_3
(TH17 can be started by il-6 or TGF-beta1 but it is my hypothesis that different cytokines result )
GP130
https://en.wikipedia.org/wiki/Glycoprotein_130
il-10 is the stop cytokine
il-10 stops pg130 cytokines (neutrophils macrophages and NKs)
il-10 stops T FH cells from secreting il-4 and il-21 which stops the GC from producing B cells
il-10 and gp130
https://www.ncbi.nlm.nih.gov/pubmed/22140267
Cytokines using Beta chains: il-3, il-5, GM-CSF are all on the myeloid side
Cytokines using Gamma chains: il-2, il-7, il-15, il-21, il-4, il-9 are all on the lymphoid side
The il-1 family cytokines and Chemokines
When an infection occurs the first cytokine made by macrophages and monocytes is the il-1 family cytokines.
il-1 family cytokines trigger cells to cytokine rain. This produces massive amounts of chemokines.
il-1 induces fibroblasts to produce chemokines which are attractant proteins.
il-1 also induces the expression of adhesion proteins so the arriving immune system knows where to stick.
The IFN family cytokines
These cytokines identify where inside the host cell the virus is hiding and coordinates the immune response attack. Which HLA to express and which TAM hands to wear.
cytosol TLR4 IFNbeta HLA-D Tyro3
Nucleus/ Mito TLR7/9 IFNalpha HLA-A HLA-B Mer
Endoplasmic R TLR 8 IFNgamma HLA-C Axl
Golgi TLR3 IFN lambda
The il-20 Family Cytokines: the H+ pore cytokines il-20, il-19, il-24, and il-26 ? this hypothesis is still being tested
il-26 and pore structure...and TLR9
https://www.ncbi.nlm.nih.gov/pubmed/?term=il-26+pore
The TH17 cells are involved with the second popping.
il-23 and il-6 trigger Th17 secreting cytokines against hiding bacteria: il-24 the golgi and il-22 the vacuoles.
(dendritic cells secrete il-23 after TLR4 stimulation and B cells secrete il-6 after TLR4 stimulation which is two sources of verification. )
When the virus is hiding in the nucleus or the mitochondria these organelles must be opened in order for the virus to be seen.
il-21 is made by Tcd8+ cells exposed to il-6 and TGF-B1 ( secreted when the mitochondria and nuclear TLR 9/7 of cells are triggered) cause Th17 to secrete il-19 the mitochondria and il-26 the nuclear pore.
Summary:
il-24 golgi
il-22 vacuoles
il-19 mitochondria ?
il-26 nuclear membrane (or extra cellular bacteria)
is il-20 the plasma membrane?
il-24 salmonella in the golgi
https://www.ncbi.nlm.nih.gov/pubmed/19830736 il-24 salmonella
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC204495/ Salmonella and golgi
il-22 inhibited autophagy
http://www.ijbs.com/v08p0249.htm
autophagy is required for hyper mucus production
https://www.ncbi.nlm.nih.gov/pubmed/26671423
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044763/
Is il-19 the mitochondria and il-26 the nucleus?
http://angelabiggs.blogspot.com/2018/02/il-19-is-mitochondrial-pore-il-26-is.html
Golgi TLR3 IFN lambda
The il-20 Family Cytokines: the H+ pore cytokines il-20, il-19, il-24, and il-26 ? this hypothesis is still being tested
il-26 and pore structure...and TLR9
https://www.ncbi.nlm.nih.gov/pubmed/?term=il-26+pore
The TH17 cells are involved with the second popping.
il-23 and il-6 trigger Th17 secreting cytokines against hiding bacteria: il-24 the golgi and il-22 the vacuoles.
(dendritic cells secrete il-23 after TLR4 stimulation and B cells secrete il-6 after TLR4 stimulation which is two sources of verification. )
When the virus is hiding in the nucleus or the mitochondria these organelles must be opened in order for the virus to be seen.
il-21 is made by Tcd8+ cells exposed to il-6 and TGF-B1 ( secreted when the mitochondria and nuclear TLR 9/7 of cells are triggered) cause Th17 to secrete il-19 the mitochondria and il-26 the nuclear pore.
Summary:
il-24 golgi
il-22 vacuoles
il-19 mitochondria ?
il-26 nuclear membrane (or extra cellular bacteria)
is il-20 the plasma membrane?
il-24 salmonella in the golgi
https://www.ncbi.nlm.nih.gov/pubmed/19830736 il-24 salmonella
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC204495/ Salmonella and golgi
il-22 inhibited autophagy
http://www.ijbs.com/v08p0249.htm
autophagy is required for hyper mucus production
https://www.ncbi.nlm.nih.gov/pubmed/26671423
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5044763/
Is il-19 the mitochondria and il-26 the nucleus?
http://angelabiggs.blogspot.com/2018/02/il-19-is-mitochondrial-pore-il-26-is.html
il-18 is the ER which means the cells have lost their self proteins and can be attacked like an infection but still need the TH17 because the infection is hiding in the ER.
il-35 is the complete stop cytokine, one level up from il-10, this cytokine stops inflammation as well as the immune reaction. The key cytokine of Treg and Breg suppressing reactions.
il-35 is secreted by T regulatory and is required for their function
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008395/
il-35 and B regulatory cells
https://f1000.com/prime/718289707
http://www.sciencedirect.com/science/article/pii/S0091674917314343
il-35 stops th17
https://www.ncbi.nlm.nih.gov/pubmed/17874423
il-35 is the complete stop cytokine, one level up from il-10, this cytokine stops inflammation as well as the immune reaction. The key cytokine of Treg and Breg suppressing reactions.
il-35 is secreted by T regulatory and is required for their function
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3008395/
il-35 and B regulatory cells
https://f1000.com/prime/718289707
http://www.sciencedirect.com/science/article/pii/S0091674917314343
il-35 stops th17
https://www.ncbi.nlm.nih.gov/pubmed/17874423
This Th17 section with the hiding infections is a hypothesis and needs to be proven.
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