TNF beta (lymphotoxin-alpha) Is secreted and worn by Bcells to stimulate Follicular Dendritic Cells. This TNF-beta is required for the Peyer Patch and secondary lymph nodes development but how is it involved in infection?
FDC are not really dendritic cells; they are non migratory cells at the lymph nodes involved in the development of Bcells
TNF C (lymphotoxin-beta) Is worn by macrophages and dendritic cells (APC) when they are infected by bacterias. The lymphotoxin receptor is on Mast cells. While TNF-alpha is secreted by macrophages infected themselves by viruses or bacteria.
lymphotoxin-beta and macrophage intracellular infection
https://www.ncbi.nlm.nih.gov/pubmed/12734369
lymphotoxin-beta receptor of mast cell triggers TLR4 and impairs TLR9
http://www.jimmunol.org/content/188/7/3426
Mast cells normally produce TGF-B1 which triggers a viral response acting on T9 cells .
When the TNF-c receptor of the mast cell is activated the TLR9 (mitochondrial virus butterfly net) is impaired and the TLR4 which is a bacterial vacuole butterfly net is focused on by the Mast cell. The Mast cells which were focused on viruses are refocused on bacterias that can infect the host's cells.
lymphotoxoin-beta also leads to il-8 release (receptor is on most cells but not B and T cells).
il-8 calls the neutrophils to poison and trap bacteria coming out of host cells
So the question is does the Bcell TNF-beta (lymphotoxin-alpha) expression match up with the possible infections of B cells?
Flu virus and Bcells with TNF
http://www.jimmunol.org/content/169/11/6193
https://onlinelibrary.wiley.com/doi/full/10.1002/eji.200626255
FDC are not really dendritic cells; they are non migratory cells at the lymph nodes involved in the development of Bcells
lymphotoxin-beta and macrophage intracellular infection
https://www.ncbi.nlm.nih.gov/pubmed/12734369
lymphotoxin-beta receptor of mast cell triggers TLR4 and impairs TLR9
http://www.jimmunol.org/content/188/7/3426
Mast cells normally produce TGF-B1 which triggers a viral response acting on T9 cells .
When the TNF-c receptor of the mast cell is activated the TLR9 (mitochondrial virus butterfly net) is impaired and the TLR4 which is a bacterial vacuole butterfly net is focused on by the Mast cell. The Mast cells which were focused on viruses are refocused on bacterias that can infect the host's cells.
lymphotoxoin-beta also leads to il-8 release (receptor is on most cells but not B and T cells).
il-8 calls the neutrophils to poison and trap bacteria coming out of host cells
So the question is does the Bcell TNF-beta (lymphotoxin-alpha) expression match up with the possible infections of B cells?
Flu virus and Bcells with TNF
http://www.jimmunol.org/content/169/11/6193
https://onlinelibrary.wiley.com/doi/full/10.1002/eji.200626255
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