Attempting to match up the TLRs of bacterial infections with the TGF-betas: added TGF-beta5

So which TLRs trigger the the TGF-Bs?  The location and the behavior of the bacterias determine which TLR

Are TGF-betas triggered to repair a damaged organelle?

TLR 7/9 and TGF-B1 : mitochondria bacteria

TLR9 stimulant produced TGF-B1
https://www.ncbi.nlm.nih.gov/pubmed/22536167

TGF-B1 and mitochondria
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444292/ 
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcp.20753

TLR9/7 and TGF-B1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372299/


TLR2/1  and TGF-B3 : Vacuole bacteria

TLR2 which senses modulins (staph example)
https://www.nature.com/articles/ncomms12304

These bacterias, like staph, if they move into cell do so through vacuoles
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3417557/

lysteria and TLR2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC375211/

TLR2 triggers  il-23 and TGF-B3 (assuming vacuole damage)


TLR2/6 with TLR4 and TGF-B2: cytosolic bacteria

TLR6 bind lipoproteins found on gram positive bacteria like strep or mycobacterias

cytosolic replication of strep in macrophages
http://mbio.asm.org/content/7/2/e00020-16.full

lipoproteins on mycobacterias
https://www.ncbi.nlm.nih.gov/pubmed/15539077

there is a cytosolic sharing between Tcells and cancer cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3813479/

TGF-B2 is high expressed by fibroblasts interacting with cancer cells
https://www.ncbi.nlm.nih.gov/pubmed/27880067/

Does TLR6 trigger il-22 and TGF-B2?

TLR
http://www.pnas.org/content/108/9/3683.full.pdf

mycobacteria triggers: tlr2 tlr6 tlr4

synergism of tlr2 tlr6 and tlr4....causes TNF alpha
https://www.ncbi.nlm.nih.gov/pubmed/19428561

TNF alpha means the immune system is infected

TLR3 and TGF-B4 : golgi bacteria

salmonella and il-24
https://www.ncbi.nlm.nih.gov/pubmed/19830736

salmonella infects the golgi

salmonella trigger tlr3 and tlr4

https://www.researchgate.net/publication/295503655_Salmonella_Suppresses_the_TRIF-Dependent_Type_I_Interferon_Response_in_Macrophages

Does tlr3 trigger il-24 and TGF-B4 ? as well as IFN beta and HLA-D?


note that the golgi and melanoma are linked
http://cancerres.aacrjournals.org/content/30/9/2326

melanoma cell death, il-24 and IFN-beta are linked
https://www.ncbi.nlm.nih.gov/pubmed/18511292


What about the ER? Mycoplasmas hide there....can this link to TGF-beta5 ?
TLR2/6

Mycoplasmas trigger TLR2 and TLR6
 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613965/

tlr2 with tlr6 trigger IFNgamma then CXCL10 (in cancer cells)
https://www.ncbi.nlm.nih.gov/pubmed/25765738

CXCL10 is the IFNgamma inducing cytokine
https://en.wikipedia.org/wiki/CXCL10

When a virus infects the ER we have already linked il-8 with IFNgamma

Obviously your immune system has already learned that the combination of tlr2 and tlr6 means something that likes to hide in the Endoplasmic reticulum (ER)

Does ER stress trigger the TGF-beta5 pathway?

ER stress and TGF-beta pathways
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247721/

The ER is intimately involved with the calcium fluxes in neurons
https://www.ncbi.nlm.nih.gov/pubmed/12543098

In amphibians TGF-beta5 has been linked to neurogenesis
http://www.jbc.org/content/265/2/1089

which makes sense if the ER's ability to flux calcium is so involved with neuron function

Can we link the TLR2 with TLR6 with TGF-beta5?

Brucella abortus also hides in the ER
https://www.ncbi.nlm.nih.gov/pubmed/9826346?dopt=Abstract

tlr6 with tlr2 detects Brucella infections
https://www.ncbi.nlm.nih.gov/pubmed/23460520

Validating the pattern