Wednesday, November 29, 2017

Looking at TGF beta when there are bacterial infections inside the cell

Looking at TGF beta for bacterial infections inside the cell: Is this growth factor for repairing the damaged organelle? Or fighting cancer?

il-17 TGF-B1 mito/nuclear infections (il-17a?)

il-23 TGF-B3 vacuoles infections

il-22 TGF-B2  cytosol infections or cancer (cytosolic exchange with T cells)

il-24 TGF- B4 golgi infection and neurulation?

Mitochondrial respiration and TGF-b1
http://www.jbc.org/content/early/2012/12/04/jbc.M112.431973.full.pdf

TGF-B1 and the appearance of the mitochondria
http://onlinelibrary.wiley.com/store/10.1002/aja.1002030304/asset/1002030304_ftp.pdf?v=1&t=jal68y40&s=122ea55960ca0b6d4b21a9aad0428cf0f75d6f47&systemMessage=Wiley+Online+Library+usage+report+download+page+will+be+unavailable+on+Friday+24th+November+2017+at+21%3A00+EST+%2F+02.00+GMT+%2F+10%3A00+SGT+%28Saturday+25th+Nov+for+SGT+

TGF-B1 and DNA repair
https://www.ncbi.nlm.nih.gov/pubmed/12384514

male infertility and TGF-b3
https://www.nature.com/articles/srep17151

spermhead vacuoles and fertility debate
https://www.hindawi.com/journals/bmri/2014/927841/

Chlamydia which infects in a vacuole triggers TGF-B3
http://iai.asm.org/content/81/12/4583.full.pdf

Tcells,  tumors, and the cytosol : there is an exchange of cytosol content
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078558

cytosolic viruses increase TGF-B2
http://onlinelibrary.wiley.com/doi/10.1002/hep.29319/abstract
http://pubmedcentralcanada.ca/pmcc/articles/PMC4583434/

il-22 is produced by cancer associated fibroblasts
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4134496/

Does mycobacteria which infects the cytosol increase TGF-B1 and  TGF-B2 ?

increased expression of the receptors in Tuberculous
https://www.ncbi.nlm.nih.gov/pubmed/12641657

Salmonella infects the golgi

Salmonella and TGF-B4
https://www.ncbi.nlm.nih.gov/pubmed/25935756

TGF-B4 higher in muscles and nerves
https://www.ncbi.nlm.nih.gov/pubmed/1304823

How much golgi exists in nerves and muscles? Is there a lot which is why the golgi was discovered in nerves?

So...T17 cells secrete cytokines: il-17a, il-23, il-22, il-24 which can stimulate repair in the areas infected through the linked TGF-beta?





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