Wednesday, December 6, 2017

Analyzing the overlap of endometriosis and ulcerative colitis

If endometriosis is connected to ulcerative colitis?  How and why? (updating 2018)

Link of endometriosis and ulcerative colitis and crohn's?
https://www.ncbi.nlm.nih.gov/pubmed/26332310
https://www.medicinenet.com/script/main/art.asp?articlekey=152823
https://www.ncbi.nlm.nih.gov/pubmed/22184069

 C.sordellii releases an acid like h.pylori, does this cause the ulcers of ulcerative colitis?

C. diff not C.sordellii? isolated from colitis
https://www.ncbi.nlm.nih.gov/pubmed/700321
https://www.ncbi.nlm.nih.gov/pubmed/625309
http://pmj.bmj.com/content/postgradmedj/63/745/955.full.pdf
http://www.gastrojournal.org/article/0016-5085(79)90345-7/abstract

specialized uterine NK cells
https://www.ncbi.nlm.nih.gov/pubmed/17100884/

estrogen controls the migration of these uNK cells and it's secretion of CCL2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498222/

Estrogen and the immune system: estrogen must drop for fertilization to occur
http://www.encognitive.com/node/3776

If Estrogen is kept high is that because a bacteria exists in the area and the immune system wants to keep uNK active?

il-22 and endometriosis
https://www.ncbi.nlm.nih.gov/pubmed/24133578

il-22 is the vacuole popping cytokine released by th17

il-22 and C.diff
https://www.ncbi.nlm.nih.gov/pubmed/25367575

c.diff in vacuoles
http://iai.asm.org/content/77/12/5478.full


endometriosis cytokines: CCL8 (which is il-8)  ,CCL2(mcp-1), CCL5 (RANTES)
https://www.ncbi.nlm.nih.gov/pubmed/24287816

CCL2 induces angiogenesis (blood vessel growth)
https://www.ncbi.nlm.nih.gov/pubmed/16888027
https://www.ncbi.nlm.nih.gov/pubmed/22265030

il-8 is the " bacteria released a TOXIN" cytokine? calling the neutrophils?

il-8 is known at the neutrophil chemotactic factor

neutrophils are critical for the early response against these types of pathogens

immune responses during toxic shock syndrome/ toxins
http://iai.asm.org/content/81/5/1751.full
http://iai.asm.org/content/77/3/1182.full

il-8 and h.pylori
http://iai.asm.org/content/73/3/1523.abstract
c.diff toxins and il-8
http://www.ncbi.nlm.nih.gov/pubmed/9435559
shiga toxin from e.coli and il-8
http://www.ncbi.nlm.nih.gov/pubmed/10531258

C.sordelii does release a toxin
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC415707/

CCL5 is a chemoattractant calling Eosinophils (histamine release) Basophils and T helper cells
https://www.sciencedirect.com/topics/neuroscience/ccl5

CCL5 aka RANTES causes the inflammation

TLR4 and clostridium
http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1002076

TLR4 and endometriosis
https://www.ncbi.nlm.nih.gov/pubmed/18596029

TLR4 binds lipopolysaccharides of bacteria : cytokines it can release IL-6, IL-8, CXCL1, CXCL2, CXCL3, and CCL2 
http://www.jbc.org/content/289/4/2457.full

c.diff cytokines:  IL-1α, IL-1β, IL-6, IL-8 and tumour necrosis factor-α 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4040718/

Ulcerative colitis and chamomile/daisy allergy: the natural remedy

endometriosis and ragweed allergy
https://www.ncbi.nlm.nih.gov/pubmed/22369407




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