Sunday, June 19, 2016

Is Steven-johnson's the cross-targeting of cox-2 inhibitors and mycoplasmas at the skin?

Autoimmune cross-targeting hypothesis suggests that simultaneous infections on one target triggers autoimmunity.  One infection on the outside of the target cell and one infection, like a virus, on the inside of the target.  

Previous I had looked at RA as autoimmune cross-targeting of mycoplasmas and epstein barr virus
http://angelabiggs.blogspot.com/2015/08/rheumatoid-arthritis-as-autoimmune.html

tumeric and arthritis..which encourages people to take against mycoplasmas
http://onlinelibrary.wiley.com/doi/10.1002/art.22180/abstract

curcumin is active against a lot of bacterias
http://www.hindawi.com/journals/bmri/2014/186864/
but is it active against the mycoplasmas of RA

However this blog suggests there is a risk to taking tumeric/curcumin against mycoplasmas

curcumin and steven-johnson's syndrome
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650986/

curcumin does more than kill bacteria it inhibits cox-2: it's anti-inflammation ability
http://curcumin-turmeric.net/inflammation.html

steven-johnson's is an autoimmune skin blistering disease...severe
https://en.wikipedia.org/wiki/Stevens%E2%80%93Johnson_syndrome

Is steven-johnson's triggered by autoimmune cross-targeting of a skin mycoplasma and a cox-2 inhibitor?

sjs and mycoplasma
http://www.ncbi.nlm.nih.gov/pubmed/629550
http://www.ncbi.nlm.nih.gov/pubmed/4687162
http://www.ncbi.nlm.nih.gov/pubmed/8912572
http://www.ncbi.nlm.nih.gov/pubmed/4050840

acetaminophen and sjs
http://healthimpactnews.com/2013/fda-warning-acetaminophen-linked-to-fatal-skin-reactions/

acetaminophen, mycoplasmas, and maculopapular rash
http://www.ncbi.nlm.nih.gov/pubmed/23289784

lamictal and SJS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905385/

lamicatal is a cox-2 inhibitor like acetaminophen
http://www.drugdevelopment-technology.com/projects/lamictal-by-gsk/

severe skin disease and cox-2 inhibitors
http://www.ncbi.nlm.nih.gov/pubmed/16872242

UV light induces cox-2 expression
http://www.ncbi.nlm.nih.gov/pubmed/9635856

normal cox-2 is expressed primarily in the nerves but if heavy sun exposure occurs and the person takes a cox-2 inhibitor....and has skin mycoplasmas...sjs occurs?

mycoplasmas can infect the skin
http://www.atmph.org/article.asp?issn=1755-6783;year=2011;volume=4;issue=2;spage=151;epage=152;aulast=Gude

Anyone with RA or recent Pneumonia taking cox-2 inhibitors should avoid sunlight.


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