How is Amyotrophic lateral sclerosis, vit D, Tau protein, and organochlorides connected?

Organochlorides can cause parkinson's and cancer by infected melanoma containing cells but they have also been linked to cases of ALS. How? Does the cl- bind vit D channels like aflatoxin? Does it then bind hsp70? is that how they are linked to the creation of Tau ?


Is ALS triggered by aflatoxin like compounds and tau is produced? Previous post i am building on.
http://angelabiggs.blogspot.com/2016/05/amyotrophic-lateral-sclerosis-and.html

aflatoxin binds the Vit D receptor
https://www.citeab.com/publication/1455664-25483621-toxicity-of-aflatoxin-b1-towards-the-vitamin-d-rece

Tau has been found to be reduced with vit D supplementation
http://www.ncbi.nlm.nih.gov/pubmed/24412233

organochloride pestides and vit D deficiency
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266254/

some forms ALS caused by organochlorides
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358481/

Vit D has been shown to slow the progression of ALS
http://www.ncbi.nlm.nih.gov/pubmed/24428861

do organochlorides bind the vit D receptor as well as the melatonin receptor?

note that the vit D receptor controls the Chloride channel
http://www.ncbi.nlm.nih.gov/pubmed/21659475

Does Cl bind these particular vit D receptors as a form of feed back regulation?

note that the organochloride "dieldrin" causes Tau protein

https://books.google.com/books?id=otQw-eo1aA0C&pg=PT314&lpg=PT314&dq=organochlorine+tau+protein&source=bl&ots=N0XaZ3LiGA&sig=tVcc99MHxHBAKZYaecytuMAY8HU&hl=en&sa=X&ved=0ahUKEwj8xIzcw4rNAhViE1IKHW18BKcQ6AEITzAH#v=onepage&q=organochlorine%20tau%20protein&f=false

Dieldrin creates the amyloid protein by destroying the mitochondria too.

organochlorides, alzheimer's, and amyloid
http://angelabiggs.blogspot.com/2016/06/is-reason-chlordane-triggers-alzheimers.html

further are there high levels of vit D receptors in breast tissue and could this explain why so much heptachlor is stored there?
http://www.ncbi.nlm.nih.gov/pubmed/7881099

note that Vit D cycles to the cytosol where it binds a type of hsp70
http://www.reactome.org/content/detail/209766

Hsp70 is known to bind tau
http://www.ncbi.nlm.nih.gov/pubmed/20308058
http://www.ncbi.nlm.nih.gov/pubmed/25882706

an imbalance of hsp70 family proteins causes tau accumulations!
http://www.ncbi.nlm.nih.gov/pubmed/23271055

Does aflatoxin or dieldrin bind not just to the vit D receptor but once in the cytosol do they bind the hsp70? is this why aflatoxin causes microtubule issues?

cells treated with aflatoxin increase expression of hsp70
http://www.ncbi.nlm.nih.gov/pubmed/15037034

previous aflatoxin post
http://angelabiggs.blogspot.com/2016/04/what-does-aflatoxin-do-mitochondria-of.html

like heptachlor does aflatoxin increase the risk of breast cancer? maybe
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567057/