Friday, June 3, 2016

Acetylcholine receptors, nitrates/nitrites, enteroviruses, and cancer

Logically cells that involve acetylcholine receptors would end up with nitrates and nitrites in them. Have the carcinogen there does not cause cancer until a virus infects the same cell.

Enteroviruses look like they infect using the same acetylcholine receptors
http://angelabiggs.blogspot.com/2015/07/enteroviruses-and-acetylcholine.html

Only when both are there does co-carcinogenesis occur resulting in cancer.

Co-carcinogenesis : Rous' hypothesis requires a virus and a carcinogen together to start cancer.

My co-carcinogenesis takes his further:  Carcinogens inhibit polymerases.

(yes we have been told carcinogens cause DNA damage but I think their ability to inhibit polymerases causes most cancer. The cancers have patterns and are not that chaotic)

Alone a carcinogen would inhibit growth until a virus appears opens up the DNA and modifies the cell to create virus supplies for ever.  The problem is the carcinogen inhibits the viral polymerase better than the human polymerase.  So instead of the virus making what it wants the infected cell is transformed into a cancer cell.

Different carcinogens are absorbed by different areas of the body. The post suggests that nitrates/nitrites are taken up by acetylcholine receptor cells.

sh groups and acetylcholine
http://www.sciencedirect.com/science/article/pii/0014579377800549

nitrates,vascular muscle relaxation and sh groups
http://www.ncbi.nlm.nih.gov/pubmed/6816463

acetylcholine is a neurotransmitter
http://www.ncbi.nlm.nih.gov/books/NBK11143/

hot dogs and brain tumors in children and pancreatic cancer in adults
http://www.processedfreeamerica.org/resources/health-news/355-hot-dogs-cause-brain-tumors-in-children

Pancreas and acetylcholine receptors
http://www.pnas.org/content/107/40/17397.full.pdf

Gastric cancer and nitrates? it is being debated
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690057/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2062934/

gastric chief cells and acetylcholine
https://en.wikipedia.org/wiki/Regulation_of_gastric_function

coxsackie infection blocked by nicotine
http://www.ncbi.nlm.nih.gov/pubmed/26851533


No comments:

Post a Comment