Autoimmune cross-targeting hypothesis suggests that simultaneous infections on one target triggers autoimmunity. One infection on the outside of the target cell and one infection, like a virus, on the inside of the target.
Pemphigoid: cox-2 inhibitiors and mycobacteria/fungal infections
Pemphigoid is an autoimmune skin blistering disease of the elderly
https://en.wikipedia.org/wiki/Pemphigoid
linked to psoriasis which is mycobacteria
http://www.ncbi.nlm.nih.gov/pubmed/17076725
UV light triggered pemphigoid in fungal skin infections
http://www.ncbi.nlm.nih.gov/pubmed/2225541
http://www.ncbi.nlm.nih.gov/pubmed/3888880
This could be similar to steven-johnson's where the cox-2 inhibitors like acetaminaphen are triggering cross-targeting when the skin cells exposed to UV causing cox-2 expression....but with these infections mycobacteria or fungal the blistering is less severe?
Steven-johnson's disease
http://angelabiggs.blogspot.com/2016/06/is-steven-johnsons-cross-targeting-of.html
Which is interesting to further consider scalded skin syndrome which is said to be staph producing a toxin which damages the skin. Is scalded skin syndrome autoimmune cross-targeting too?
Pemphigoid: cox-2 inhibitiors and mycobacteria/fungal infections
Pemphigoid is an autoimmune skin blistering disease of the elderly
https://en.wikipedia.org/wiki/Pemphigoid
linked to psoriasis which is mycobacteria
http://www.ncbi.nlm.nih.gov/pubmed/17076725
UV light triggered pemphigoid in fungal skin infections
http://www.ncbi.nlm.nih.gov/pubmed/2225541
http://www.ncbi.nlm.nih.gov/pubmed/3888880
This could be similar to steven-johnson's where the cox-2 inhibitors like acetaminaphen are triggering cross-targeting when the skin cells exposed to UV causing cox-2 expression....but with these infections mycobacteria or fungal the blistering is less severe?
Steven-johnson's disease
http://angelabiggs.blogspot.com/2016/06/is-steven-johnsons-cross-targeting-of.html
Which is interesting to further consider scalded skin syndrome which is said to be staph producing a toxin which damages the skin. Is scalded skin syndrome autoimmune cross-targeting too?
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