Thursday, June 23, 2016

Pemphigoid and autoimmune cross-targeting

Autoimmune cross-targeting hypothesis suggests that simultaneous infections on one target triggers autoimmunity.  One infection on the outside of the target cell and one infection, like a virus, on the inside of the target.  

Pemphigoid: cox-2 inhibitiors and mycobacteria/fungal infections

Pemphigoid is an autoimmune skin blistering disease of the elderly
https://en.wikipedia.org/wiki/Pemphigoid

linked to psoriasis which is mycobacteria
http://www.ncbi.nlm.nih.gov/pubmed/17076725

UV light triggered pemphigoid in fungal skin infections
http://www.ncbi.nlm.nih.gov/pubmed/2225541
http://www.ncbi.nlm.nih.gov/pubmed/3888880

This could be similar to steven-johnson's where the cox-2 inhibitors like acetaminaphen are triggering cross-targeting when the skin cells exposed to UV causing cox-2 expression....but with these infections mycobacteria or fungal the blistering is less severe?

Steven-johnson's disease
http://angelabiggs.blogspot.com/2016/06/is-steven-johnsons-cross-targeting-of.html

Which is interesting to further consider scalded skin syndrome which is said to be staph producing a toxin which damages the skin.  Is scalded skin syndrome autoimmune cross-targeting too?










No comments:

Post a Comment