Thursday, February 26, 2015

Right now Fibromyalgia looks like an infection that the immune system has not beaten.

Older post:
Xanthomonas is a bacteria that infects nightshade plants.  They use butyrolactones as signalling molecules between them.

In our bodies butyrolactones is converted to GHB which is then converted to GABA.  GABA is the neurotransmitter. How our nerves talk to each other.

A form of Xanthomonas has been found to infect the respiratory tract of people and is considered a new bacterial genus: named Stenotrophomonas.

My notion is actually a question: does the Stenotrophomonas still make these signalling molecules when exposed to nightshades like a bell pepper when it infects us? Could this explain the painful reactions to nightshades that Fibromyalgia patients have? Are antibodies directed at the butyrolactones causing antibodies to GABA thus causing one's own immune system to attack our nerves?

New post

Osteoarthritis and bone spurs appear to overlap with fibromyalgia. Do these diseases have associations with Stenotrophomonas?

weaker immune system in fibro
http://www.fmnetnews.com/latest-news/defend-yourself-with-a-good-nights-sleep

Osteoarthritis and Fibro...and lower back pain
http://www.ncbi.nlm.nih.gov/pubmed/21833699
http://www.ncbi.nlm.nih.gov/pubmed/21833699

septic arthritis and stenotrophomonas
http://www.ncbi.nlm.nih.gov/pubmed/18365601

septic arthritis overlapping osteoarthritis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1004540/

Brain sees the pain of osteoarthritis and fibromyalgia as similar
http://www.nursingtimes.net/nursing-practice/specialisms/public-health/link-found-between-osteoarthritis-and-fibromyalgia-pain/5068745.article


If this infection likes the lungs we should see an area of overlap for Fibromyalgia and osteoarthritis of dysnpnea.

Trouble breathing and Fibromyalgia
http://www.fibromyalgia-symptoms.org/fibromyalgia_breathing.html
http://www.ncbi.nlm.nih.gov/pubmed/2809502
http://www.ncbi.nlm.nih.gov/pubmed/2244193

dyspnea and fibromyalgia
http://journal.publications.chestnet.org/data/Journals/CHEST/21757/246.pdf

Dyspnea and osteoarthritis
http://www.ehealthme.com/cs/osteoarthritis/dyspnea


dyspnea caused by osteophytes (bone spurs)
http://www.ncbi.nlm.nih.gov/pubmed/22679683
http://www.ncbi.nlm.nih.gov/pubmed/19393122
http://www.ncbi.nlm.nih.gov/pubmed/2043228

fibromyalgia and osteophytes
https://www.facebook.com/permalink.php?story_fbid=643025715732617&id=632999116735277

Case of a bone spur operation involving an infection....of Stentorophomonas
http://www.avvo.com/legal-answers/do-i-have-a-case-for-medical-malpractice--433638.html
note that I am saying the infection was already there and not from the surgery

Bone marrow transplants and strentorophomonas
http://www.ncbi.nlm.nih.gov/pubmed/10619754

Thyroid issues in fibro
http://www.ncbi.nlm.nih.gov/pubmed/22549342
http://www.ncbi.nlm.nih.gov/pubmed/17487449

Note that it appears that Chronic fatigue is different and involves epstein barr aka mono possibly infecting the nerves and the pineal gland....maybe. Herpes viruses tend to come in and out of latency and that could be what we are seeing for chronic fatigue.

New thoughts 11/20/2015
Pituitary growth hormone from pituitary tumors has been paired with osteoarthritis. Does Stenotrophomonas go to the pituitary? what starts a pituitary tumor? How would stenotrophomona effect the pituitary?

pituitary and fibromyalgia
http://www.ncbi.nlm.nih.gov/pubmed/9676772

pituitary and dyspnea
http://www.ncbi.nlm.nih.gov/pubmed/26142980
http://www.ncbi.nlm.nih.gov/pubmed/17346913

pituitary and osteoarthritis (Growth hormone)
http://www.hindawi.com/journals/ije/2012/839282/

pituitary and ovary (FSH)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777809/

pituitary and ovarian cysts
http://www.ncbi.nlm.nih.gov/pubmed/25457522
http://www.ncbi.nlm.nih.gov/pubmed/24119690

fibro and cysts
http://www.ncbi.nlm.nih.gov/pubmed/16572917
http://www.clinchem.org/content/52/6/1208.full

Here is a case of crushing syndrome induced by supplementation of GHB
http://www.eje-online.org/content/157/6/779.long

My thoughts: the stenotrophomonas make butyrolactones which is converted to GHB in our bodies. Do chronic infections of strenotrophomonas cause pituitary issues through GHB? The infection doesn't even go to the pituitary?

bone marrow transplant and stenotrophomona
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327432/
http://www.ncbi.nlm.nih.gov/pubmed/11816260
http://www.ncbi.nlm.nih.gov/pubmed/17267464

bone spurs and osteoarthritis
http://www.ncbi.nlm.nih.gov/pubmed/25048110

cellulitis and stenotrophomona
http://www.ncbi.nlm.nih.gov/pubmed/11816260

4-hydroxybutanoic acid GHB or the "date rape drug"

crushing disease and pituitary
https://www.nlm.nih.gov/medlineplus/ency/article/000348.htm

 Fibromyalgia and pituitary
http://www.ncbi.nlm.nih.gov/pubmed/9676772

Gaba causes pituitary hormone secretion changes
http://www.ncbi.nlm.nih.gov/pubmed/3020896
http://www.ncbi.nlm.nih.gov/pubmed/6089244

lower back pain and osteoarthritis
http://www.ncbi.nlm.nih.gov/pubmed/23307577

osteoarthritis, in patients with longterm cure of acromegaly
http://www.eje-online.org/content/160/3/357.full.pdf







Tuesday, February 24, 2015

Cross-targeting of the brain and spinal causes autoimmunity

The basal ganglia is involved for Tourettes but it is not an autoimmune but a genetic disease.
The gene involves changes of histamine production in the basal ganglia
http://www.medicalnewstoday.com/articles/271058.php
Could this be triggered by allergies? Tourettes is no longer viewed as autoimmune on this blog. Pandas which is similar in symptoms I do consider as autoimmune.

This is an Autoimmune hypothesis blog.

Hypothesis:
The cross-targeting of  2 infections on one target triggers autoimmunity.  A virus marks the inside and a bacteria, mycobacteria or larger type of infection marks the outside. The target is clearly important in determining which autoimmune disease develops. Note that the larger infection which breaks the blood brain barrier creates the hole letting the virus in behind it.  Then they infect their target.

This page is an over view and a contemplation while the rest of this blog has reference links.

Basal ganglia autoimmunity: Pandas (tourettes like)
Herpes Simplex hhv1 or flu virus / mycobacteria or strep

 The herpes viruses wax and wane out of latency which could explain the coming and going of symptoms.  Note that OCD has been found in some Alzheimer's patients which would be in the herpes group because the herpes virus infects the mitochondria of cells.  Alzheimer's is a disease of mitochondrias no longer functioning.

Hypocretin neurons autoimmunity: narcolepsy
swine flu H1N1 / strep
http://www.ima.org.il/FilesUpload/IMAJ/0/95/47598.pdf
http://healthysleep.med.harvard.edu/narcolepsy/what-is-narcolepsy/science-of-narcolepsy

Periphery nerves autoimmunity: Guilian barre syndrome
Epstein barr (hhv4) or flaviviruses or flu ? / Campylobacteria Jejuni/ sutterella or mycoplasmas

Substantia Nigra autoimmunity: Parkinson's
avian flu H5N1 / mycobacteria (psoriasis connected )

Amygdala autoimmunity :schizophrenia
t.gondii or mycobacteria / herpes simplex virus or epstein barr? (hhv1or hhv4)

link showing schizophrenia and amygdala connection
http://ajp.psychiatryonline.org/doi/abs/10.1176/appi.ajp.2008.08020261

Hypothalamus autoimmunity : seizures
t.gondii / enteroviruses
note that nodding disease might fall here too

Temporal lobe autoimmunity: Autism after dtp
enteroviruses or herpes 6 (hhv6) / tetanus

Frontal lobe autoimmunity: born with Autism
flu virus / mycoplasmas (rheumatoid arthritis)

Cerebellum autoimmunity: Autsim after MMR
Measles virus/ sutterella bacteria

interesting personal post about pick's and autism
http://www.healthboards.com/boards/autism-spectrum/409658-autism-frontal-lobe-dementia.html

Anterior horn cells of the spinal cord autoimmunity:  ALS
enterovirus like polio/ Trichophyton at the nerve endings? (it does make us itch)
note that at least 10% of ALS is a genetic not the infectious cause and the gene  C9orf72
What this gene does is currently unknown but it probably involves nerve endings.

post polio syndrome and als
http://postpolio.ofoonr.lublin.pl/PPS-conf/Abstract_PPS.ALS_en.pdf

Anterior horn cells autoimmunity : paralysis kids of denver
d68 enterovirus and staph from asthma/eczema
(anterior horn cells are in the spinal cord)

Autoimmunity of nerves : Multiple sclerosis
herpes zoster hhv3/ psoriasis mycobacterias or eczema staph

There are 3 different types of autism covered by this blog and they involve different areas of the brain.

Cerebellum: MMR and sutterella
Temporal lobe: DTP and 6th disease (herpes 6)
Frontal lobe: mother's RA autoimmunity  producing antibodies attacking brain and then the mothers catch the flu

All of the large infections that cross the blood brain barrier can or will be associated with gluten sensitivity: strep, t.gondii, e.coli, candida, sutterella, and mycobacterias.

Barrier crossing infections cross both the intestine and the blood brain barrier.  When they cross the intestine however they do not cause celiac disease.  E.coli infects the intestine itself and when cross targeted with a stomach virus triggers the autoimmune disease celiac disease.  Celiac patients tend to have a history of bladder infections in addition to gluten sensitivity. Or at least that is the prediction of my hypothesis.







Friday, February 20, 2015

Maternal antibodies causes one form of autism which is distinct from the regressive types


Rheumatoid arthritis as an autoimmune disease of the mother can effect the unborn child.
A reason to keep inflammation down while pregnant and a huge reason to get flu shots multiple years before planning a pregnancy.

Autoimmune cross-targeting hypothesis:
The cross-targeting of  2 infections on one target triggers autoimmunity.  A virus marks the inside and a different infection marks the outside. The target is clearly important in determining which autoimmune disease develops.  In this case the mycoplasmas of RA produce antibodies against the frontal lobe. Normally the blood brain barrier protects the brain but this is not fully developed in an embryo. If the pregnant mother with RA catches the flu virus cross-targeting on the frontal lobe can occur because the flu virus when it has access to the brain replicates in the frontal lobe.  The outside and the inside of the baby's frontal lobe's neurons are attacked by the immune system because of the cross-targeting of these infections.  Thus I am suggesting this is why the baby is born with autism.


Frontal lobe and maternal antibody caused autism
http://www.ncbi.nlm.nih.gov/pubmed/23395715
http://www.ncbi.nlm.nih.gov/pubmed/22911883

Maternal antibodies caused monkey's brains to grow abnormal in the frontal lobe
http://www.ncbi.nlm.nih.gov/pubmed/23838889

Rheumatoid arthritis, autism, and maternal antibodies
http://sfari.org/news-and-opinion/news/2013/large-study-links-autism-to-autoimmune-disease-in-mothers

Flu during pregnancy increase autism
http://www.webmd.com/brain/autism/news/20121109/flu-pregnancy-autism

Flu virus if it has access to the brain infects the frontal lobe
http://www.ncbi.nlm.nih.gov/pubmed/10788752
http://www.ncbi.nlm.nih.gov/pubmed/17094568

These children would be born autistic. They would not be the recessive kind of autism seen in previous posts. They are not vaccine triggered.  The area of the brain attacked by the immune system is different thus these autism should have some symptoms that are different.

my posts of RA as a cross-targeting autoimmune disease in adults
http://angelabiggs.blogspot.com/2014/11/autoimmune-cross-targeting-could-cause.html

my posts of Autism as the recessive forms:
the cerebellum form involving ataxia
http://angelabiggs.blogspot.com/2015/02/mmr-vaccine-overlapping-with-sutterella.html
the temporal lobe form involving hearing issues
http://angelabiggs.blogspot.com/2015/02/dtp-vaccine-reactions-and-6th-disease.html
These are different from the autism we are looking at here.


Autism and seizures have been seen together
http://www.ncbi.nlm.nih.gov/pubmed/25599987
http://www.ncbi.nlm.nih.gov/pubmed/16932856
http://www.ncbi.nlm.nih.gov/pubmed/15791919
This last reference is important in that it states the the regressive form of autism does not have the comorbidity with epilepsy?

The flu virus does infect the basal ganglia.

(But here it sounds like the MMR/sutterella autism might have seizures
http://www.ncbi.nlm.nih.gov/pubmed/18766162
http://www.ncbi.nlm.nih.gov/pubmed/23666039
 this must be due to the connections of the cerebellum and hypothalamus
http://www.ncbi.nlm.nih.gov/pubmed/2644872)

Are the seizures in this case of immediate autism are from the RA and it's effect on the hypothalamus
http://www.clinexprheumatol.org/article.asp?a=2652

Lupus in children and the presence of seizures
http://www.ncbi.nlm.nih.gov/pubmed/8554655

Adults with lupus complications including seizures
http://www.ncbi.nlm.nih.gov/pubmed/18537650

Absent seizure with MG and lupus in a child
(mycoplasmas with polio/enterovirus)
http://www.ncbi.nlm.nih.gov/pubmed/9294315
http://www.ncbi.nlm.nih.gov/pubmed/4999164
http://www.ncbi.nlm.nih.gov/pubmed/5483199
http://www.ncbi.nlm.nih.gov/pubmed/5433055

Rheumatoid arthritis, mycoplasmas, and seizures
http://www.ncbi.nlm.nih.gov/pubmed/17690887
http://www.ncbi.nlm.nih.gov/pubmed/19049505
http://www.ncbi.nlm.nih.gov/pubmed/15066670 (anti cardio lipin)
cardiolipin antibodies and RA
http://www.ncbi.nlm.nih.gov/pubmed/3664159

Wednesday, February 18, 2015

Kikuchi-Fujimoto disease is this caused by autoimmune cross-targeting?

Hypothesis: Autoimmune disease is triggered when 2 infections cross-target on one cell type.  A virus hhv-6 marks in the inside and an infection like aspergillus marks the outside which in Kikuchi-Fujimoto disease is the lymph node cells.

Kikuchi-Fujimoto disease is an autoimmune disease of the lymph nodes
http://www.ncbi.nlm.nih.gov/pubmed/25574175
http://www.ncbi.nlm.nih.gov/pubmed/20121621
Most common in asia

Which viruses infect the lymph nodes and are associated with Kikuchi?
Note that it can be any one of these with the outer infection

hhv-8
http://www.medicinenet.com/script/main/art.asp?articlekey=11476
hhv-8 infects the lymph node
http://www.ncbi.nlm.nih.gov/pubmed/15832089

hhv-6
http://www.ncbi.nlm.nih.gov/pubmed/12659352
infects the lymph node and can cause mono like symptoms
http://hhv-6foundation.org/associated-conditions/hhv-6-mononucleosis-lymphadenopathy

EBV
http://www.ncbi.nlm.nih.gov/pubmed/18787614
causes mono....infects the lymph nodes

Parvovirus
http://www.ncbi.nlm.nih.gov/pubmed/22939574
note that parvovirus infects the lymph nodes
http://www.ncbi.nlm.nih.gov/pubmed/8136290

Which outer infection is involved?

Sjogren's, lupus, and kikuchi seem to be connected.
http://www.ncbi.nlm.nih.gov/pubmed/16465479
http://link.springer.com/article/10.1007%2Fs10067-005-0184-z?LI=true
http://www.ncbi.nlm.nih.gov/pubmed/12928530
http://www.ncbi.nlm.nih.gov/pubmed/20082108
http://www.ncbi.nlm.nih.gov/pubmed/21713349
http://www.ncbi.nlm.nih.gov/pubmed/18465190

Earlier posts I had associated sjogren's with candida like infections.

Is Kikuchi-Fugimoto a fungal infection in the lymph node cross-targeting with one of these viruses?
What fungal infection of Japan is this?

Most sinus fungal infections in Japan are Aspergillus
http://www.hindawi.com/journals/ijoto/2013/731640/

Aspergillus oryzae in Japan is common
http://www.nature.com/nature/journal/v438/n7071/abs/nature04300.html
A. oryzae is used for making miso, soy sauce, and sake in Japan and workers have been inhaling them.

vitiligo and sjogren's in japan
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715204/
is this connected????

This autoimmune disease will continue to be analyzed and updated because the connections are weak.







Sunday, February 15, 2015

Does Cross-targeting autoimmunity cause Febrile seizures after the pertussis vaccine?

Does pertussis cause seizures by an autoimmune-cross targeting similar to t.gondii because it infects the hypothalamus?  do the pieces of vaccine although unable to cause whooping cough still migrate to and cause autoimmunity at the hypothalamus?

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while an infection marks the outside and the combination triggers autoimmune disease.

Is this pertussis reaction like the t.gondii and the black fly parasite? Does pertussis overlap with an enterovirus causing autoimmune seizures? (previous posts looked at t.gondii and such parasites connections to seizures)

Febrile seizures after pertussis vaccine
http://jama.jamanetwork.com/article.aspx?articleid=1355993
http://www.ncbi.nlm.nih.gov/pubmed/22368426

Evidence of enteroviruses in Febrile seizures
http://www.ncbi.nlm.nih.gov/pubmed/9041348
http://www.ncbi.nlm.nih.gov/pubmed/11134476

Hypothalamus involvement with pertussis
http://www.ncbi.nlm.nih.gov/pubmed/13921428

The connection of the hypothalamus to seizures has been investigated.
http://emedicine.medscape.com/article/1186872-overview

(remember that t.gondii infections involve the amygdala and hypothalamus and that schizophrenia has high rates of seizures but it is unclear if infants have infections)

Previous post which looked at nodding disease and seizures:
http://angelabiggs.blogspot.com/2015/01/nodding-disease-epilepsy-seizuresare.html


Thursday, February 12, 2015

MMR vaccine overlapping with sutterella causing ataxia and GI associated A?

Get vaccinated. Vaccines save lives. This blog is for researchers.

Hypothesis: autoimmunity is triggered by the cross-targeting of infections. A virus marking the inside of the host's cell and a bacteria-like infection marks the outside.  If autism is autoimmune it will have one of each.  Note that there are different types of autoimmune autism and this page deals with one form of regressive autism.

DTP and herpes 6 virus = deafness/ hearing connected autism? (previous post)

MMR and sutterella = ataxia and GI connected autism? (this post)

See newer post 3/17/15 .....MMR or hepatitis B vaccine....with sutterella cross-targeting on the astrocytes which encase the purkinje fibers.

The measles vaccine causes a temporary change in  purkinje cells of dogs which I think is evidence that pieces reach there and so do the antibodies
http://www.unboundmedicine.com/medline/citation/4725276/[Atrophy_of_Purkinje_cells_following_measles_virus_vaccination_in_the_dog]_

MMR and autism controversy links the GI group with the MMR vaccine not the DTP group...(Richler 2006)
https://books.google.com/books?id=BP86uPB3bi8C&pg=PA77&lpg=PA77&dq=mmr+autism+ataxia&source=bl&ots=D90SYYQMfz&sig=Il7FEZ-ZO5cvPeSQZIqwEh7_AzQ&hl=en&sa=X&ei=nTrdVPm2IMWxyQS1-YLIAg&ved=0CCUQ6AEwAA#v=onepage&q=mmr%20autism%20ataxia&f=false

GI of autism and sutterella
http://www.ncbi.nlm.nih.gov/pubmed/22233678

Sutterella is a bacteria of waste and appears in areas where the sewer systems are outdated and overflow.  The sutterella bacteria is a barrier crosser of the intestine and/or the blood brain barrier and therefore causes gluten sensitivity.  Gluten is able to use the "hole" then accelerates and increases the existing inflammation.  So this autism group will have the gluten ataxia associated with it. (this group will not have the herpes associated amyloid or the hearing issues of the temporal lobe)

Sutterella should be found at the purkinje fibers and the measles virus pieces would bring the antibodies there too.  The virus pieces can't cause disease but they can trigger auto-immunity. The cross-targeting is occurring on the purkinje fibers, I believe, in this form of autism.

Consensus paper about autism and the involvement of the cerebellum where purkinje fibers are.
http://www.researchgate.net/publication/221867052_Consensus_paper_pathological_role_of_the_cerebellum_in_autism

Small groups of 25 have not confirmed this and larger studies need to be done not for autism specifically not for the autism spectrum, not for dtp triggered autism or for autism with deafness, or aspergers but for the autistic group that has gluten sensitive and regressive autism with ataxia issues after the MMR vaccine.

Purkinje : movement disorders, ataxia, and autism
http://www.sciencedaily.com/releases/2014/06/140605140232.htm
http://www.ncbi.nlm.nih.gov/pubmed/19325647

Autoimmune attack of purkinje can cause ataxia
https://books.google.com/books?id=LYIKAQAAQBAJ&pg=PA189&lpg=PA189&dq=england+ataxia+purkinje+cell+loss&source=bl&ots=5OJpGlTnkP&sig=5BNcXc0BeAiJoOkgImqM5JQ7l4c&hl=en&sa=X&ei=6jbdVL7DIpazyATq54K4Bg&ved=0CCsQ6AEwAjgK#v=onepage&q=england%20ataxia%20purkinje%20cell%20loss&f=false

The MMR/sutterella autism might have seizures
http://www.ncbi.nlm.nih.gov/pubmed/18766162
http://www.ncbi.nlm.nih.gov/pubmed/23666039
 this must be due to the connections of the cerebellum and hypothalamus
http://www.ncbi.nlm.nih.gov/pubmed/2644872



DTP vaccine reactions and 6th disease?

GET VACCINATED.  Vaccines save lives.

Hypothesis: autoimmunity is triggered by the cross-targeting of a virus marking the inside of the cell and an infection marking the outside.  One of each. If autism is autoimmune we can find one of each when it is triggered.

Can DTP vaccines cause autism but only if  a herpes 6 viral infection involved?  This blog is not proven and only for researchers.

Autism and autoimmune antibodies
http://www.ncbi.nlm.nih.gov/pubmed/10228297

Pervasive development disorder
http://www.autismfile.com/treatment-therapy/it%E2%80%99s-working-my-child-is-coming-back-to-me

Hearing and autism
http://sfari.org/news-and-opinion/news/2013/controversial-study-uncovers-hearing-glitch-in-autism
This form of autism involves the temporal lobe which is the part of the brain involved in hearing.

What is the DTP vaccine for? Which part of the vaccine could be causing the cross-targeting?

diptheria
A gram positive bacteria which makes a toxic coating that suffocates it's victims

tetanus
A gram positive bacteria which makes a nerve/brain toxin which causes "lockjaw" etc.

pertussis
 The whopping cough bacteria is a respiratory infection that can suffocate thus killing infants.


The tentanus vaccine is made up of deactivated tentanus toxins.
http://en.wikipedia.org/wiki/Tetanus_vaccine

The tentanus toxin can act on the temporal lobe of the brain.  This is the region of the brain that one processes hearing. Is this the autoimmune target in this form of autism? are fragments of the toxin making it there and then the antibodies are reacting?


Is it the herpes 6 virus ( Roseola )the culprit for cross-targeting because it replicates in the temporal lobe?

 Some autistic kids have anti-herpes 6 (not just anti-measles are found)
http://www.ncbi.nlm.nih.gov/pubmed/9756729

6th disease (herpes 6)
http://www.emergingworlds.com/ch_viruses_detail.cfm?vPageid=41
This is what the rash looks like:
http://www.medicinenet.com/roseola/article.htm#what_is_roseola
Are these the kids that should not get the DTP vaccine ? should the vaccine not be given when this virus is circulating?

Here are cases of autism following herpes encephalitis.

http://www.encephalitis.info/images/iPdf/Resources/AutisticSymptoms.pdf
http://deepblue.lib.umich.edu/bitstream/handle/2027.42/44606/10803_2005_Article_BF01046406.pdf?se
https://books.google.com/books?id=7IeCiVA6BbMC&pg=PA87&lpg=PA87&dq=temporal+lobe+autism+herpes&source=bl&ots=piMbK6xMG_&sig=1wuV7sJouqwORHRtyt4HipHph50&hl=en&sa=X&ei=ZgzdVILrNISMyATIjIGoBA&ved=0CDoQ6AEwAw#v=onepage&q=temporal%20lobe%20autism%20herpes&f=false

Here is a case of deafness following tentanus vaccine.

Temporal lobe: part of the brain which processes the auditory information (hearing)
http://brainmadesimple.com/temporal-lobe.html

How did the herpes get passed the blood brain barrier? Herpes ride the mitochondria of nerves...moving from one nerve ending to another. They not travel in the blood. They seem to travel through the spinal cord?
http://neuropathologyblog.blogspot.com/2009/02/why-does-herpes-virus-love-temporal.html

If that is the case then alzheimer's like symptoms should appear.  App has been found in autistic kids like alzheimer's
http://www.medscape.com/viewarticle/543630
http://sfari.org/news-and-opinion/in-brief/2012/molecular-mechanisms-alzheimers-protein-linked-to-autism

Do 2 groups of regressive autism after vaccine exist?

MMR and sutterella (rare bacteria of flood zones) with gluten sensitivity and GI issues

DTP and herpes virus with hearing issues and app plaques

Both are an autoimmune attack caused by the cross-targeting of a bacteria overlapping a virus.

Monday, February 9, 2015

Autoimmune Cross-targeting hypothesis summary



   The triggers of autoimmunity have been evasive.  A virus will only trigger autoimmunity in a small number of cases and we have not been able to predict who is vulnerable.  This autoimmune hypothesis is an attempt to put forth a reasonable mechanism that allows not just prediction but also an explanation as to why more than one virus can trigger autoimmunity and why not all the time.

   Genetic susceptibility to infections can play a role in the development of autoimmunity, for example the HLA gene of celiac disease is a mailbox protein for Tcells.   Autoimmunity may run in families but this is a shared genetic weakness to infections hence explaining also why there seems to be no specific age of autoimmune development.  Genetic susceptibility is not required to develop an autoimmune disease.

   My autoimmune cross-targeting hypothesis suggests that the development of autoimmune disease is triggered when 2 infections coexist in the target or make the immune system attack the same target through antibodies.  Cross-targeting literally means attacking from different platforms.  This hypothesis is that  the immune system attacks large infections on the outside of cells while simultaneously attacking the inside because of viral infections and in the process removes the self education.  Nothing stops the destruction of the entire target cell.

   Viruses enter host cells through receptors.  Not all cells have the same receptors so a virus can only trigger autoimmunity in cells they have access to.  Consider Type one diabetes as an example, the flu virus replicates in  pancreas cells and when the flu moves through a population more cases of type 1 diabetes appear.  Not everyone who gets the flu gets diabetes only a small percent that have an outer pancreatic infection do.

   My cross targeting hypothesis suggests that another infection exists in the pancreas in order to trigger the autoimmunity.  Rheumatoid arthritis has been linked with mycoplasmas and mycoplasmas can very easily infect a pancreas.  Note that other infections can replace the mycoplasmas.  Bladder infections and celiac disease have also been linked to type one diabetes.  If e.coli which is often the cause of bladder infection is the culprit here it could not only infect the pancreas but make anti- insulin antibodies because e.coli produces insulin like proteins.  Please note that  I can not prove that these second infections exist but based on the associations I think we should look for them.  It seems logical that if the inside and the outside of the host's pancreatic cells were marked for destruction at the same time that this could set off autoimmunity.  Also note that the coxsackie virus also infects the pancreas and could replace the flu virus in this scenario.

This autoimmune-cross targeting hypothesis can be applied to other diseases.  This blog has been gathering references to test the notion that this happens in all cases. The difference is which host cells are infected.  For example multiple sclerosis patients tend to have skin issues like psoriasis which has mycobacteria associations.  Interestingly multiple sclerosis appears after shingles in some patients.   Could this be the marking of the inside and outside of a nerve?  Any thoughts out there ?