Chemically induced autoimmunity could occur through cross-targeting autoimmunity
Chloroetheylene induces autoimmunity
http://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/875
Chloroetheylenes are absorbed by the nerves and muscles
http://en.wikipedia.org/wiki/Trichloroethylene
In addition to the immediate chemical reactions causing illness, if a patient has a preexisting infection marking the outside of any of these cells which absorb the chloroetheylene they could have autoimmunity triggered. Chemicals absorbed into cells would be marked as containing foreign material just as if infected by a virus.
Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease. The immune system is instructed to destroy both the inside and the outside of the target.
If a patient had RA mycoplasmas they could have the joints attacked. If the patient had liver disease with anti-muscle antibodies then lupus could be triggered. If the patient merely had psoriasis or eczema then multiple sclerosis could be triggered. The key pattern here is that the outside and the inside of a target tissue is marked for autoimmune disease to be triggered.
Chloroetheylene induces autoimmunity
http://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/875
Chloroetheylenes are absorbed by the nerves and muscles
http://en.wikipedia.org/wiki/Trichloroethylene
In addition to the immediate chemical reactions causing illness, if a patient has a preexisting infection marking the outside of any of these cells which absorb the chloroetheylene they could have autoimmunity triggered. Chemicals absorbed into cells would be marked as containing foreign material just as if infected by a virus.
Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease. The immune system is instructed to destroy both the inside and the outside of the target.
If a patient had RA mycoplasmas they could have the joints attacked. If the patient had liver disease with anti-muscle antibodies then lupus could be triggered. If the patient merely had psoriasis or eczema then multiple sclerosis could be triggered. The key pattern here is that the outside and the inside of a target tissue is marked for autoimmune disease to be triggered.
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