Friday, May 15, 2015

Idiopathic pericarditis is it caused by autoimmune cross-targeting?


Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.


Idiopathic pericarditis could be a fungus marking the outside with a virus like coxsackie or echo-virus  marking the inside of the myocyte.

Sjogren's and Pericarditis (fungus)
http://www.ncbi.nlm.nih.gov/pubmed/17435839

Hashimoto's and pericarditis (fungus)
http://www.ncbi.nlm.nih.gov/pubmed/25791974

Colchicine and pericarditis where the drug appears to make an impact
http://www.ncbi.nlm.nih.gov/pubmed/16186437

Colchicine is a microtubule inhibitor
http://www.febsletters.org/article/S0014-5793(07)01029-0/abstract

Tuberculous pericarditis (could replace the fungus marking the outside)
http://www.ncbi.nlm.nih.gov/pubmed/8170726

Viruses and pericarditis
http://www.ncbi.nlm.nih.gov/pubmed/18708165 (coxsacke or echo-virus)
http://www.ncbi.nlm.nih.gov/pubmed/25760570 (epstein-barr)
http://circ.ahajournals.org/content/119/19/2615.full.html (review of heart viruses)

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