Friday, May 8, 2015

idopathic achalasia as an autoimmune disease triggered by cross-targeting

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.

idiopathic achalasia has been connected with autoimmune disease
http://www.sciencedaily.com/releases/2014/07/140729073644.htm
http://www.ncbi.nlm.nih.gov/pubmed/15929777
It may or may not be autoimmune itself

the virus could be varicella zoster
http://www.ncbi.nlm.nih.gov/pubmed/8386130
or herpes
http://www.ncbi.nlm.nih.gov/pubmed/23973923

idiopathic achalasia could be triggered by a throat infection
like h.pylori as the large infection
http://www.ncbi.nlm.nih.gov/pubmed/15325006

I think another choice is Candida/ fungal infections for the "outer" infection

Very high rate of  uveitis with achalasia

uveitis which is swelling of the middle layer or region of the eye
http://www.ncbi.nlm.nih.gov/pubmed/21899655

what are the types of uveitis

http://www.merckmanuals.com/professional/eye-disorders/uveitis-and-related-disorders/overview-of-uveitis

vitiligo and uveitis

http://www.ncbi.nlm.nih.gov/pubmed/7195407
http://www.ncbi.nlm.nih.gov/pubmed/6869476

vitiligo and candida antigens
http://www.ncbi.nlm.nih.gov/pubmed/23252470

uveitis and candida
http://www.ncbi.nlm.nih.gov/pubmed/25870216

Hashimoto's and achalasia patterns indicate that maybe 1/4 of cases are fungal
http://www.wjgnet.com/1007-9327/13/594.pdf
http://www.ncbi.nlm.nih.gov/pubmed/23329193
http://www.ncbi.nlm.nih.gov/pubmed/17278227
http://www.ncbi.nlm.nih.gov/pubmed/21899655




chagas which is caused by t.cruzi can cause achalasia
http://en.wikipedia.org/wiki/Chagas_disease

comparing chagas to idiopathic achalasia (they are different)

http://www.ncbi.nlm.nih.gov/pubmed/20545981




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