Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease. The immune system is instructed to destroy both the inside and the outside of the target.
idiopathic achalasia has been connected with autoimmune disease
http://www.sciencedaily.com/releases/2014/07/140729073644.htm
http://www.ncbi.nlm.nih.gov/pubmed/15929777
It may or may not be autoimmune itself
the virus could be varicella zoster
http://www.ncbi.nlm.nih.gov/pubmed/8386130
or herpes
http://www.ncbi.nlm.nih.gov/pubmed/23973923
idiopathic achalasia could be triggered by a throat infection
like h.pylori as the large infection
http://www.ncbi.nlm.nih.gov/pubmed/15325006
I think another choice is Candida/ fungal infections for the "outer" infection
Very high rate of uveitis with achalasia
uveitis which is swelling of the middle layer or region of the eye
http://www.ncbi.nlm.nih.gov/pubmed/21899655
what are the types of uveitis
http://www.merckmanuals.com/professional/eye-disorders/uveitis-and-related-disorders/overview-of-uveitis
vitiligo and uveitis
http://www.ncbi.nlm.nih.gov/pubmed/7195407
http://www.ncbi.nlm.nih.gov/pubmed/6869476
vitiligo and candida antigens
http://www.ncbi.nlm.nih.gov/pubmed/23252470
uveitis and candida
http://www.ncbi.nlm.nih.gov/pubmed/25870216
Hashimoto's and achalasia patterns indicate that maybe 1/4 of cases are fungal
http://www.wjgnet.com/1007-9327/13/594.pdf
http://www.ncbi.nlm.nih.gov/pubmed/23329193
http://www.ncbi.nlm.nih.gov/pubmed/17278227
http://www.ncbi.nlm.nih.gov/pubmed/21899655
chagas which is caused by t.cruzi can cause achalasia
http://en.wikipedia.org/wiki/Chagas_disease
comparing chagas to idiopathic achalasia (they are different)
http://www.ncbi.nlm.nih.gov/pubmed/20545981
idiopathic achalasia has been connected with autoimmune disease
http://www.sciencedaily.com/releases/2014/07/140729073644.htm
http://www.ncbi.nlm.nih.gov/pubmed/15929777
It may or may not be autoimmune itself
the virus could be varicella zoster
http://www.ncbi.nlm.nih.gov/pubmed/8386130
or herpes
http://www.ncbi.nlm.nih.gov/pubmed/23973923
idiopathic achalasia could be triggered by a throat infection
like h.pylori as the large infection
http://www.ncbi.nlm.nih.gov/pubmed/15325006
I think another choice is Candida/ fungal infections for the "outer" infection
Very high rate of uveitis with achalasia
uveitis which is swelling of the middle layer or region of the eye
http://www.ncbi.nlm.nih.gov/pubmed/21899655
what are the types of uveitis
http://www.merckmanuals.com/professional/eye-disorders/uveitis-and-related-disorders/overview-of-uveitis
vitiligo and uveitis
http://www.ncbi.nlm.nih.gov/pubmed/7195407
http://www.ncbi.nlm.nih.gov/pubmed/6869476
vitiligo and candida antigens
http://www.ncbi.nlm.nih.gov/pubmed/23252470
uveitis and candida
http://www.ncbi.nlm.nih.gov/pubmed/25870216
Hashimoto's and achalasia patterns indicate that maybe 1/4 of cases are fungal
http://www.wjgnet.com/1007-9327/13/594.pdf
http://www.ncbi.nlm.nih.gov/pubmed/23329193
http://www.ncbi.nlm.nih.gov/pubmed/17278227
http://www.ncbi.nlm.nih.gov/pubmed/21899655
chagas which is caused by t.cruzi can cause achalasia
http://en.wikipedia.org/wiki/Chagas_disease
comparing chagas to idiopathic achalasia (they are different)
http://www.ncbi.nlm.nih.gov/pubmed/20545981
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