Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease. The immune system is instructed to destroy both the inside and the outside of the target.
Looking at chemical triggers and Parkinson's. Cross-targeting at the substantia nigra could occur not just with a virus like the flu or west nile it could be a chemical marking the inside of the neurons.
west-nile virus infects the substantia nigra
http://www.ncbi.nlm.nih.gov/pubmed/14568817
influenza A and the substantia nigra
http://www.ncbi.nlm.nih.gov/pubmed/11385275
http://www.ncbi.nlm.nih.gov/pubmed/21655265
http://www.ncbi.nlm.nih.gov/pubmed/10507986
Atrazine is absorbed by the substantia nigra and has been connected to parkinson's but how is still unclear. It is a herbicide that can build up in well water.
http://www.mdpi.com/1422-0067/
Weirdly the mycobacteria eats the atrazine (could be irrelevant )
http://www.ncbi.nlm.nih.gov/pubmed/25603295
Mycoplasmas or norcardia, they are similar, still would have to mark the outside of the substantia nigra neurons to trigger autoimmunity. Further they must be the first infection.
http://www.ncbi.nlm.nih.gov/pubmed/25459140
http://www.ncbi.nlm.nih.gov/pubmed/8420152
Older posts on my blog about parkinson's
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