Drug induced autoimmunity could be cross-targeting autoimmunity

Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while a larger infection marks the outside and the combination triggers autoimmune disease.  The immune system is instructed to destroy both the inside and the outside of the target.

Drug induced lupus is when the muscles are targeted by the immune system
http://en.wikipedia.org/wiki/Drug-induced_lupus_erythematosus

Autoimmune liver disease produces anti-muscle antibodies marking the outside of the muscles
http://en.wikipedia.org/wiki/Anti-smooth_muscle_antibody

Hydralazine is a smooth muscle relaxant and goes inside of muscles (so instead of a virus marking the inside of the muscle it is hydralazine)
http://en.wikipedia.org/wiki/Hydralazine

Monocycline which is an antibiotic for acne appear to also get inside of muscles hence the muscle cramps of the patients taking the drug again replacing the virus for marking the inside


Drug induced Hemolytic anemia has the reverse scenario where the drug is marking the outside of the red blood cells
http://en.wikipedia.org/wiki/Autoimmune_hemolytic_anemia

Red blood cells become coated with penicillin
http://asheducationbook.hematologylibrary.org/content/2009/1/73.full

The virus in this case is hepatitis C (or any other virus that can infect red blood cells...they can try but red blood cells have  no nucleus or mitochondria to replicate in)
http://www.ncbi.nlm.nih.gov/pubmed/11799634

Another option would be a bone marrow virus like RSV
http://www.atsjournals.org/doi/full/10.1165/rcmb.2010-0121OC#.VT8EySFViko
a virus changing what is on the inside before it becomes a Red blood cell

RSV and anemia associations
http://www.sciencedirect.com/science/article/pii/S1201971213000544