Autoimmune cross-targeting hypothesis: a virus marks the inside of a cell while an infection marks the outside and the combination triggers autoimmune disease.
Malaria
Infects the kidney of Sugar cane workers at higher rates because the Plasmodium type of parasite grows on the sugar cane.
Chronic Kidney disease of Central America
http://www.npr.org/blogs/goatsandsoda/2015/02/04/383628551/new-clues-to-mysterious-kidney-disease-afflicting-sugar-cane-workers
http://investigations.nbcnews.com/_news/2012/10/16/13866856-mystery-kidney-disease-decimates-central-america-sugarcane-workers
Kenya, malaria and sugar cane
http://www.ncbi.nlm.nih.gov/pubmed/9754665
Sri Lanka battles malaria too
http://globalhealthsciences.ucsf.edu/sites/default/files/content/ghg/mei-eliminating-malaria-sri-lanka-lowres.pdf
Adenoviruses suspects in Central America
http://www.ncbi.nlm.nih.gov/pubmed/19903214
21% are subgroup B which can infect the kidney
The other option is Glyphosate which is a pesticide used in central America and in Sri Lanka.
http://www.ncbi.nlm.nih.gov/pubmed/25596925
http://www.publicintegrity.org/2014/03/13/14418/sri-lanka-bans-monsanto-herbicide-citing-potential-link-deadly-kidney-disease
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3945589/
The pesticide would enter into kidney cells marking the inside as foreign instead of the virus. (not requiring any binding of metals to set the reaction off)
If the person has both infections at the same time or exposure to a pesticide that migrates into kidney cells cross-targeting autoimmunity can be triggered....or at least that is my hypothesis.
We already know that adenoviruses are a serious problem with Kidney transplants.
http://www.ncbi.nlm.nih.gov/pubmed/14533942
http://www.ncbi.nlm.nih.gov/pubmed/20946204
In a non immunocompromised patient adenoviruses may manifest differently.
Is chronic kidney disease an autoimmune disease?
Antibodies to EPO in chronic kidney disease
http://www.nature.com/ki/journal/v81/n8/full/ki2011500a.html
Anti-erythropoietin (EPO) antibodies help against malaria. EPO is made in the kidney
http://www.nature.com/icb/journal/v83/n6/full/icb200589a.html
http://iai.asm.org/content/early/2013/10/09/IAI.00929-13.full.pdf
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