Friday, January 31, 2014

Lon enzyme has involvement in virulence, morphology, and is stimulated by casein...gluten too?

This hypothesis was disproven. T.gondii and strep are not dimorphic. See newer gluten posts.

LON is the enzyme I am attempting to associate with gluten and casein for the dimorphic switching of infections...causing our immune systems to develop sensitivity to them.

NEWER post: http://angelabiggs.blogspot.com/2014/03/lon1-and-dimorphic-switching-caused-by.html

lon enzyme
http://www.ncbi.nlm.nih.gov/pubmed/15501647 

E.coli Lon and morphology (changes between rod and filament forms)
http://www.ncbi.nlm.nih.gov/pubmed/23391222

Campylobactor (lon protein contributes to virulence)
http://www.ncbi.nlm.nih.gov/pubmed/17933920

Mycobacteria Lon
 casein sensitive
http://www.ncbi.nlm.nih.gov/pubmed/11045626  
http://www.ncbi.nlm.nih.gov/pubmed/9698372

Mycobacteria are dimorphic (changes morphology like e.coli does with LON into a cording form)
http://mic.sgmjournals.org/content/26/1/97

T.gondii and proteases and virulence ? (it might not be t.gondii but mycobacteria with this form of  schizophrenia )
http://www.ncbi.nlm.nih.gov/pubmed/22202120

not sure how this fits:  HU is involved with t.gondii virulence ( mutated in e.coli HU causes filamentation)
http://ec.asm.org/content/11/7/905.full
lon protease degrades HU...so would this explain gluten/casein and t.gondii?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298136/

or there is more than one type of schizophrenia which is the most logical conclusion given that Tuberculosis has a risk of schizophrenia
http://www.biomedcentral.com/1471-2334/13/351

Monday, January 27, 2014

parkinson's, olfactory dysfunction, and mycobacterias of the sinus? or h. pylori!

Trying to determine which, if any, mycobacterias are the culprits for Parkinson's disease and how this fits with the cross-targeting.

Tuberculous has been connected to parkinson's through a protein called Parkin
http://medicalxpress.com/news/2013-09-tuberculosis-parkinson-disease-linked-unique.html
to dispose of mitochondria....parkin is involved.  Parkin disposes of mycobacterias too.

(note that our mitochondria maybe have in our evolutionary past evolved from something like a mycobacteria)  If we are infected with Mycobacteria could we have too much parkin in our systems which could damage us? or could parkin be something we have autoantibodes against triggering parkinson's?

Parkinson's does have autoantibodies:
http://www.ncbi.nlm.nih.gov/pubmed/21234712

How can we connect parkinson's to mycobacteria? the olfactory ?

Parkinson's and mycobacteria/ and similar infections
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC228573/

Mycobacterium leprae which causes leprosy also causes the olfactory bulb to shrink
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431526

non tuberculous mycobacteria in sinus from water and soil (plumbing)
http://www.ncbi.nlm.nih.gov/pubmed/23017381

Mycobacterium avium (most non tuberculous infections)  
http://www.ncbi.nlm.nih.gov/pubmed/23460008

 The person to person mycobacteria is Mycobacterium tuberculosis

psoriasis and tuberculous
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331879

crohn's and mycobacteria
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031217


Mycobacteria breaks the blood brain barrier: BBB allowing any  virus/ immune system cells to cross

H1n1  then causing the cross-targeting on the brain?

This could explain this recent outbreak
http://www.mumbaimirror.com/mumbai/others/2nd-wave-H1N1-stumps-docs/articleshow/16029319.cms
where the flu seemed to have a second wave of attack moving beyond the lungs and infecting the nerves, spine, and in some cases the brain...the brain may have been those with mycobactera infections? This puts the virus infecting the nerves inside and mycobacteria would infect the outside of nerves.   (cross targeting the immune system on these nerves)

Did the Micheal J. Fox parkinson's cluster in Canada have the flu or tuberculous?

Lots of possibilities here.  This page is still under construction and may change.

Here is the older post I had looking at il-6 and the bird flu
 http://angelabiggs.blogspot.com/2013/04/parkinsons-disease.html

added FEB /2014
Here is the other mystery: H.pylori
Some parkinson's patients have H.pylori infections causing ulcers and reflux and when it is treated have their symptoms improve.

H.pylori and parkinson's?
http://www.ncbi.nlm.nih.gov/pubmed/24117797
http://www.ncbi.nlm.nih.gov/pubmed/22071847

Is there a relationship between h.pylori and mycobacteria? how similar are they? do the same drugs kill them? do they coexist? i didn't think h.pylori existed outside of the digestive track.  Could this infection do the same thing?

coexist?
http://www.ncbi.nlm.nih.gov/pubmed/12613749?dopt=Abstract&otool=stanford
H.pylori can be in the sinus! (nasal polyps)
http://www.ncbi.nlm.nih.gov/pubmed/22926364
olfactory? the infection of h.pylori can alter taste and smell!
http://www.ncbi.nlm.nih.gov/pubmed/23845559
wow...h.pylori can even raise il-6
http://www.ncbi.nlm.nih.gov/pubmed/24453409

So Parkinson's could be caused by mycobacteria or h.pylori....cross targeting with the virus? Can H.pylori break the BBB? blood brain barrier.   if they infect the same areas the target might match...would they infect the dopamine neurons? does mycobacteria?

Heliobacteria pylori (h.pylori) used to be called Campylocateria pylori. We know that Campylobacteria Jejuni infects the peripheral nerves which could trigger Guillianbarre syndrome.  Realizing that h.pylori is a relative of  C. jejuni...it is extremely likely that it could infect neurons.

So we have a puzzle: mycobacterias have the ability to cross the BBB.  H.pylori does not.  which one is the culprit or are they both?





Friday, January 17, 2014

susac syndrome and cross-targeting autoimmunity

Cross-targeting:  the layering of 2 different infections on one target causing autoimmune disease.  A viral infection marking the inside. A larger infection marking the outside. In this case the target would be the small blood vessels.

 Autoimmune Triad: encephalopathy, hearing loss and microangiopathy of the retina (can be mixed up with MS)....autoimmune attack of the endothelial cells at the smallest blood vessels of the brain ?

antibodies and endothelial in susac's
http://www.ncbi.nlm.nih.gov/pubmed/19643446

the same antibodies are in lupus and sjogren's
http://www.ncbi.nlm.nih.gov/pubmed/9256310

anti-phospholipids lupus or sjogren's overlap?
http://www.ncbi.nlm.nih.gov/pubmed/15462492

could sjogren's tinnitus, itchy ear overlap with the hearing loss of Susac?  I have candida possibly linked to sjogren's which would grow on the blood vessel walls.  Do fungal infections cause itchy ears?

virus triggers : hepatits C or HIV?
HIV and susac
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766273
hepatits C and susac
http://www.researchgate.net/publication/38079571_Susac_syndrome_a_case_report_and_PET_imaging_findings 
Hepatitis makes sense because it can make antibodies that mark the small blood vessels!
http://www.webmd.com/hepatitis/hepc-guide/conditions-associated-with-hepatitis-c

Edothelial cells, blood brain barrier, MS
http://www.ncbi.nlm.nih.gov/pubmed/19442163