Friday, January 17, 2014

susac syndrome and cross-targeting autoimmunity

Cross-targeting:  the layering of 2 different infections on one target causing autoimmune disease.  A viral infection marking the inside. A larger infection marking the outside. In this case the target would be the small blood vessels.

 Autoimmune Triad: encephalopathy, hearing loss and microangiopathy of the retina (can be mixed up with MS)....autoimmune attack of the endothelial cells at the smallest blood vessels of the brain ?

antibodies and endothelial in susac's
http://www.ncbi.nlm.nih.gov/pubmed/19643446

the same antibodies are in lupus and sjogren's
http://www.ncbi.nlm.nih.gov/pubmed/9256310

anti-phospholipids lupus or sjogren's overlap?
http://www.ncbi.nlm.nih.gov/pubmed/15462492

could sjogren's tinnitus, itchy ear overlap with the hearing loss of Susac?  I have candida possibly linked to sjogren's which would grow on the blood vessel walls.  Do fungal infections cause itchy ears?

virus triggers : hepatits C or HIV?
HIV and susac
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766273
hepatits C and susac
http://www.researchgate.net/publication/38079571_Susac_syndrome_a_case_report_and_PET_imaging_findings 
Hepatitis makes sense because it can make antibodies that mark the small blood vessels!
http://www.webmd.com/hepatitis/hepc-guide/conditions-associated-with-hepatitis-c

Edothelial cells, blood brain barrier, MS
http://www.ncbi.nlm.nih.gov/pubmed/19442163

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