Monday, January 27, 2014

parkinson's, olfactory dysfunction, and mycobacterias of the sinus? or h. pylori!

Trying to determine which, if any, mycobacterias are the culprits for Parkinson's disease and how this fits with the cross-targeting.

Tuberculous has been connected to parkinson's through a protein called Parkin
http://medicalxpress.com/news/2013-09-tuberculosis-parkinson-disease-linked-unique.html
to dispose of mitochondria....parkin is involved.  Parkin disposes of mycobacterias too.

(note that our mitochondria maybe have in our evolutionary past evolved from something like a mycobacteria)  If we are infected with Mycobacteria could we have too much parkin in our systems which could damage us? or could parkin be something we have autoantibodes against triggering parkinson's?

Parkinson's does have autoantibodies:
http://www.ncbi.nlm.nih.gov/pubmed/21234712

How can we connect parkinson's to mycobacteria? the olfactory ?

Parkinson's and mycobacteria/ and similar infections
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC228573/

Mycobacterium leprae which causes leprosy also causes the olfactory bulb to shrink
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3431526

non tuberculous mycobacteria in sinus from water and soil (plumbing)
http://www.ncbi.nlm.nih.gov/pubmed/23017381

Mycobacterium avium (most non tuberculous infections)  
http://www.ncbi.nlm.nih.gov/pubmed/23460008

 The person to person mycobacteria is Mycobacterium tuberculosis

psoriasis and tuberculous
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331879

crohn's and mycobacteria
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3031217


Mycobacteria breaks the blood brain barrier: BBB allowing any  virus/ immune system cells to cross

H1n1  then causing the cross-targeting on the brain?

This could explain this recent outbreak
http://www.mumbaimirror.com/mumbai/others/2nd-wave-H1N1-stumps-docs/articleshow/16029319.cms
where the flu seemed to have a second wave of attack moving beyond the lungs and infecting the nerves, spine, and in some cases the brain...the brain may have been those with mycobactera infections? This puts the virus infecting the nerves inside and mycobacteria would infect the outside of nerves.   (cross targeting the immune system on these nerves)

Did the Micheal J. Fox parkinson's cluster in Canada have the flu or tuberculous?

Lots of possibilities here.  This page is still under construction and may change.

Here is the older post I had looking at il-6 and the bird flu
 http://angelabiggs.blogspot.com/2013/04/parkinsons-disease.html

added FEB /2014
Here is the other mystery: H.pylori
Some parkinson's patients have H.pylori infections causing ulcers and reflux and when it is treated have their symptoms improve.

H.pylori and parkinson's?
http://www.ncbi.nlm.nih.gov/pubmed/24117797
http://www.ncbi.nlm.nih.gov/pubmed/22071847

Is there a relationship between h.pylori and mycobacteria? how similar are they? do the same drugs kill them? do they coexist? i didn't think h.pylori existed outside of the digestive track.  Could this infection do the same thing?

coexist?
http://www.ncbi.nlm.nih.gov/pubmed/12613749?dopt=Abstract&otool=stanford
H.pylori can be in the sinus! (nasal polyps)
http://www.ncbi.nlm.nih.gov/pubmed/22926364
olfactory? the infection of h.pylori can alter taste and smell!
http://www.ncbi.nlm.nih.gov/pubmed/23845559
wow...h.pylori can even raise il-6
http://www.ncbi.nlm.nih.gov/pubmed/24453409

So Parkinson's could be caused by mycobacteria or h.pylori....cross targeting with the virus? Can H.pylori break the BBB? blood brain barrier.   if they infect the same areas the target might match...would they infect the dopamine neurons? does mycobacteria?

Heliobacteria pylori (h.pylori) used to be called Campylocateria pylori. We know that Campylobacteria Jejuni infects the peripheral nerves which could trigger Guillianbarre syndrome.  Realizing that h.pylori is a relative of  C. jejuni...it is extremely likely that it could infect neurons.

So we have a puzzle: mycobacterias have the ability to cross the BBB.  H.pylori does not.  which one is the culprit or are they both?





No comments:

Post a Comment