Thursday, May 31, 2018

Two types of Mast cells

The two types of mast cells are derived from different sources. Both involve high levels of Histamine to dilate the capillaries and bring more immune cells to the inflammation site.

The bone marrow mast cell is involved with fungal and bacterial infections.  The TLRs for this bone mast cell are: TLR2 lipoproteins, TLR4 LPS, and the TLR5 flagellin tails which are all basic traits of bacterias and fungal infections.  Bone mast cells secrete GM-csf when encountering vacuole bacteria, il-5, TNFalpha, and il-33.

The skin mast cell is involved with viral infections.  The TLRs it has are the internal ones that snag viruses. TLR7 of the nucleus, TLR9 of the mitochondria, and TLR3 of the golgi.  Skin mast cells secrete TGF-b1, il-21, TNFalpha, and il-1. 

bone vs skin mast cell reference

What is fascinating here is that skin mast cells wear IgE when allergies exist.  Toxins like snake venom, bee venom, or staph toxin damage the mitochondria.  Mice that are deficient in TLR9 do not have the normal anaphlylatic reactions to these toxins. 

venom and tlr9

looking for ref of venom and tlr9 def mice

peanut allergy and tlr9

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