Two types of COPD : emphysema and chronic bronchitis
Looking at COPD : there appears to be a type of COPD that has high eosinophils due to infections/toxins in the cytosol and a type of COPD that involves 25 HC and viral infections.
COPD: emphysema and bacteria/mycobacteria infections of the cytosol
emphysema and mycobacteria
http://imj.ie/rare-case-of-non-tuberculous-mycobacterial-a-diagnostic-dilemma/
Eosinophil COPD subgroup
https://journal.chestnet.org/article/S0012-3692(16)60762-6/pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405469/
il-17 with the il-8 COPD
https://www.ncbi.nlm.nih.gov/pubmed/21996014
il-17 and il-22 COPD
https://clinicaltrials.gov/ct2/show/NCT02655302
The immune system is looking for a bacterial/mycobacteria infection in the cytosol. Note that il-22 is the vacuole pore. il-17A calls neutrophils by stimulating il-8.
infections and eosinophilia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515572/
TB and eosinophilia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337757/
https://www.bmj.com/content/2/4154/220
Basophils and COPD
http://erj.ersjournals.com/content/46/suppl_59/PA384
COPD: Bronchitis
COPD and Viral infections
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962752/
acute vs chronic bronchitis (viral vs smoking)
https://www.inogen.com/blog/acute-vs-chronic-bronchitis-understanding-differences/
Smoking tobacco COPD connection
https://www.ncbi.nlm.nih.gov/pubmed/21996014
http://erj.ersjournals.com/content/29/3/438
COPD and 25HC (snags viruses)
http://erj.ersjournals.com/content/38/Suppl_55/p3903
TLR3 triggers IFNbeta or cytosolic receptors for viruses trigger IFNbeta
macrophages and dendritic cells secrete 25HC with ifn alpha and ifn beta
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996899/
http://www.pnas.org/content/pnas/106/39/16764.full.pdf
influenza virus is a non-encapsulated which involves 25HC
https://www.researchgate.net/publication/264634507_25-Hydroxycholesterol_acts_as_an_amplifier_of_inflammatory_signaling
influenza involves complement with IgG2
http://jvi.asm.org/content/81/7/3487.full
Looking at COPD : there appears to be a type of COPD that has high eosinophils due to infections/toxins in the cytosol and a type of COPD that involves 25 HC and viral infections.
COPD: emphysema and bacteria/mycobacteria infections of the cytosol
emphysema and mycobacteria
http://imj.ie/rare-case-of-non-tuberculous-mycobacterial-a-diagnostic-dilemma/
Eosinophil COPD subgroup
https://journal.chestnet.org/article/S0012-3692(16)60762-6/pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5405469/
il-17 with the il-8 COPD
https://www.ncbi.nlm.nih.gov/pubmed/21996014
il-17 and il-22 COPD
https://clinicaltrials.gov/ct2/show/NCT02655302
The immune system is looking for a bacterial/mycobacteria infection in the cytosol. Note that il-22 is the vacuole pore. il-17A calls neutrophils by stimulating il-8.
infections and eosinophilia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515572/
TB and eosinophilia
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337757/
https://www.bmj.com/content/2/4154/220
Basophils and COPD
http://erj.ersjournals.com/content/46/suppl_59/PA384
COPD: Bronchitis
COPD and Viral infections
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3962752/
acute vs chronic bronchitis (viral vs smoking)
https://www.inogen.com/blog/acute-vs-chronic-bronchitis-understanding-differences/
Smoking tobacco COPD connection
https://www.ncbi.nlm.nih.gov/pubmed/21996014
http://erj.ersjournals.com/content/29/3/438
COPD and 25HC (snags viruses)
http://erj.ersjournals.com/content/38/Suppl_55/p3903
TLR3 triggers IFNbeta or cytosolic receptors for viruses trigger IFNbeta
macrophages and dendritic cells secrete 25HC with ifn alpha and ifn beta
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996899/
http://www.pnas.org/content/pnas/106/39/16764.full.pdf
influenza virus is a non-encapsulated which involves 25HC
https://www.researchgate.net/publication/264634507_25-Hydroxycholesterol_acts_as_an_amplifier_of_inflammatory_signaling
influenza involves complement with IgG2
http://jvi.asm.org/content/81/7/3487.full
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