IFNbeta and intracellular bacteria or cytosolic virus
https://www.ncbi.nlm.nih.gov/pubmed/18771559
Rig-1 or MDA5 are cytosolic receptors for cytosolic viruses....triggers IFNbeta
https://www.sciencedirect.com/science/article/pii/S1074761306003943
viruses with either rig-1 or MDA5
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808934/table/tbl01/
All the RIG-1 viruses are HLA-dr linked
All the MDA5 viruses are HLA-dq linked
polymorphisms of MDA5receptors correlate with type one diabetes
https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.201696273
type one diabetes has been linked to celiac disease
celiac disease has been linked to Reoviruses
TLR4 can trigger IFN-b1 like the cytosolic receptors
TLR4 and flu virus through tram and trif
http://jvi.asm.org/content/86/1/19.full
How does the TLR4 know it is a virus and not a bacteria?
How does TLR3 which is the butterfly net for the golgi know it is a cytosolic virus? Is it indiscriminate ?
https://www.ncbi.nlm.nih.gov/pubmed/18771559
Rig-1 or MDA5 are cytosolic receptors for cytosolic viruses....triggers IFNbeta
https://www.sciencedirect.com/science/article/pii/S1074761306003943
viruses with either rig-1 or MDA5
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3808934/table/tbl01/
All the RIG-1 viruses are HLA-dr linked
All the MDA5 viruses are HLA-dq linked
polymorphisms of MDA5receptors correlate with type one diabetes
https://onlinelibrary.wiley.com/doi/pdf/10.15252/embj.201696273
type one diabetes has been linked to celiac disease
celiac disease has been linked to Reoviruses
TLR4 can trigger IFN-b1 like the cytosolic receptors
TLR4 and flu virus through tram and trif
http://jvi.asm.org/content/86/1/19.full
How does the TLR4 know it is a virus and not a bacteria?
How does TLR3 which is the butterfly net for the golgi know it is a cytosolic virus? Is it indiscriminate ?
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