Saturday, March 24, 2018

Does RIG-1 and MDA5 trigger TGF-B2?

Rig-1 and MDA5 are cytosolic receptors for viruses while TLRs (7/9/8/3)  are the butterfly nets for the organelles capturing viruses.

I am trying to link RIG-1 and MDA5 to TGF-b2 

TLR 7/9 TGF-b1 mitochondria growth
TLR 4  TGF-b3  vacuole growth
TLR3  TGF-b4 golgi growth

Does Rig-1/ MDA5 trigger TGF-b2 plasma membrane growth ???

Rig-1 and membrane ruffling
https://www.researchgate.net/figure/RIG-I-localizes-to-actin-enriched-membrane-ruffles-in-HEK293-and-U2OS-cells-A-and-B_fig1_23719880

TGF-b2 and cigarette smoke
https://www.atsjournals.org/doi/pdf/10.1165/rcmb.2007-0104OC

Cigarette smoke and RIG-1
https://www.physiology.org/doi/full/10.1152/ajplung.00267.2010

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