Thursday, April 17, 2014

Rasussen's encephalitis and autoimmunity

An autoimmune disease of the brain which overlaps schzophrenia in that it has autoantibodies to the NMDA receptor and the Acetylcholine receptor.

T.gondii has been indicated as the infection that could be opening the blood brain barrier and possibly producing the NMDA autoantibodies.

Two different viruses could trigger the cross-targeting: the epstein barr virus and the cytomegalovirus. The culprit will be the one that has a one hemisphere spreading pattern and research is currently ongoing to attempt to isolate the virus in these patients.

In infants:
http://www.ncbi.nlm.nih.gov/pubmed/23716471

I am not sure if this is the autoimmune type of cross-targeting or not.  T.gondii appears to trigger more molecular mimicry.  (see schizophrenia posts)

Cross-targeting is  the layering of 2 different infections on one target causing autoimmune disease.  A viral infection marking the inside. A larger infection marking the outside.

Wednesday, April 16, 2014

Sorting the types of dementia and brain diseases


This page is under construction...hypothesis not proven (links and references coming)

http://apt.rcpsych.org/content/15/5/364.full
(rare dementias)

Vascular dementia is extremely common and is caused by a lack of  blood to the brain.  These can occur after a stroke or from a vascular disease like Binswanger.

Alcoholic dementia causes Korsakoff where a person makes up information they can't remember and actually believe the fabrications. 

Most of this blog post will be focused on the other forms of dementia and mental disease.   

Frontal temporal lobe dementia:

Semantic dementia FTD: "the loss of words" Which has been strongly linked to viral infections

Behavioral variant FTD:  which has the loss of social behavior, conduct, and impulse control. Which has been linked to Pick's disease where Tau proteins form Lewy bodies.

Progressive nonfluent aphasia FTD:  which involves speech production, stuttering, and apraxia. This form has been linked to blood clots creating a stroke

The 4th type is connected with ALS, amyotrophic lateral sclerosis.


The confusing part is figuring out which diseases are, if any,  autoimmune cross-targeting and which are just the virus causing dementia having used an infection to break the blood brain barrier only.

 Autoimmune cross-targeting is when two infections tell the immune system to attack the same target.  A virus marks the inside and the larger infection marks the outside. The overlapping immune system ends up having a stronger response and attacking the tissue/cell type not just the infection.

Only a few infections are know to have the ability to cross the blood brain barrier with ease leaving a "hole behind them" : strep, mycobacterias, candida, aspergillus, t.gondii, and sutterella/campylobacteria.

Group Aspergillus

Updated March 30 with Aflotoxin hypothesis and Tau protein.  Aspergillus may explain how people with Asperger's has both Intestinal ganglioneurmatosis and Pick's disease associations. Both diseases have Tau protein. Aspergillus makes aflatoxin which may cause the tau.  (I am guessing this because my ALS fungal suspect also makes an aflatoxin like compound and it too has tau found at the damaged nerves)

 Frontotemporal dementia (pick's disase)
http://www.ncbi.nlm.nih.gov/pubmed/24966676

Note that Pick's disease is associated with Tau plaques.
http://www.ncbi.nlm.nih.gov/pubmed/8960316

Group Herpes virus

For Behcet's disease the infection culprits are Streptococcus sanguinis and herpes simplex

Temporal lobes and Herpes simplex virus?
http://neuropathologyblog.blogspot.com/2009/02/why-does-herpes-virus-love-temporal.html

Herpes simplex viruses destroy the mitochondria of cells then ride the mitochondria down the axon in order to reach the next nerve to infect.  (think of herpes zoster and shingles where it starts in the nerves of the spinal cord then travels outward following the nerve branching)

Alzheimer's is ultimately when the mitochondrias break and stop working. Mitochondrias can break more than one way which is why Tau is not always present.

group
 Herpes zoster virus and the nerves radiating from the spinal cord and temporal lobe

Includes MS (with psoriasis triggering the autoimmune not eczema)

In order for the virus to reach the brain but must have something that opens the BBB? The mycobacteria connected with psoriasis can do this but not the staph connected to eczema.

Group
Hepatits C and ring formation of plaques

Incudes: Susac's disease and Balo's MS

Group 
diacetyl group (too much fake butter/chardonnay ) In excess this damages the mitochondria
(not an infection so it can cross to the brain without help) or radicals damage

Includes Alzheimer's of early onset? Downsyndrome?

A note about amyloid plaques : I think they are due to the mitochondria not moving down the nerve root because diacetyl  (or herpes virus ) has destroyed the mitochondria.  I have a post where I suggest that app is a serine protease is involved with nerve growth. (neuroserpin would be the off switch) When the mitochondria does not move into place the nerve tries to ramp up growth.....maybe this is all guessing.
Amyloid  plaques might be discarded calling cards.


Group
Mycobacterias

Includes:
parkinson's ( avian flu virus N5H1 cross-targeting?)
PANDAS (some are mycobacteria not strep crossed with flu H1N1?)
shy-drager ( cross-targeting suspect m.fortuitum but not proven)



Group
Strep

gluten ataxia, pandas, narcolepsy

gluten ataxia
http://www.ncbi.nlm.nih.gov/pubmed/15814071

Pandas (H1N1 or herpes zoster with the strep) note that different virus triggers are possible just like mycobacteria can replace strep.  the target is more important than the infections

Pandas involves the midbrain region of the basal ganglia
http://www.slideshare.net/rossfinesmith1/pandas72 

Remember from above H5N1 as a Parkinson's trigger was located in the midbrain dopamine neurons SNpc structure...which i suspect is the same in the pandas group. Specifically Pandas is the basal ganglia with strep and parkinson's is the Substantia Nigra with mycobacterias

Pineal Gland autoimmunity: narcolepsy
swine flu H1N1 / strep
http://www.ima.org.il/FilesUpload/IMAJ/0/95/47598.pdf

 
Group
Sutterella / Campylobacteria

 Autism of the cerebellum (autoimmune cross targeting with a virus...measles there)
Guilian barre syndrome typically states in the periphery nerves but can on occasion cross to the cerebellum. sutterella is a relative and is easily confused with campylobacteria.
Guilian barre is the HHV4 cross-targeting with camypylobacteria

 Group
Flu virus

Autism of the Frontal lobe
A fetus does not have a developed blood brain barrier so some will be at the mercy of the mother's immune system during pregnancy. RA can have antibodies against the frontal lobe which because of the underdeveloped BBB can reach the area. RA is considered associated with autism risk.  The flu virus can also replicate in the frontal lobe of the brain.  Mother's who have had the flu have been found to have higher rates of autism in newborn children.

Parkinson's flu H5n1

Narcolepsy flu H1n1 or vaccine for it and strep
http://healthysleep.med.harvard.edu/narcolepsy/what-is-narcolepsy/science-of-narcolepsy


Group
T. gondii

Includes schizophrenia and Rasussen's encephalitis

Schizophrenia is from t.gondii at the amygdala of the brain.

Rasussen's encephalitis has left hemisphere inflammation and the viral culprit that is under consideration causing the cross-targeting is the cytomegalvirus CMV and/or the epstein Barr virus.  Biopsies currently being researched to determine which virus is present.

Infants with a similar disease have CMV.
http://www.ncbi.nlm.nih.gov/pubmed/23716471

LEWY BODIES:  all plaques of the different proteins tend to get lumped into this description.  Amyloid plaques, synuclien plaques, and tau plaques.  The reasons they build up are different and more then one type can appear in one dementia.   I dislike this term because it is confusing and prefer to focus on the specific type of plaques.

Monday, April 7, 2014

Balo disease and cross-targeting autoimmunity

Balo disease is a rare form of multiple sclerosis that effects young adults and children...occasionally adults.

The MS brain plaques look like tree rings in the MRI.

Hypothesis: cross-targeting of 2 infections causes the immune system to attack.  In this case one infection must be able to cross the blood brain barrier.  Mycobacterias can cross this barrier and could be how the virus gains access to the brain. Or does the virus gain access to the child's brain before birth if the mother is the virus carrier?  To set off the autoimmunity I still think you would need 2 infections marking the nerve.

Regular multiple sclerosis I had associated the herpes virus like HHV-6 with MS. In this case a patient with balo-like plaques was found to have hepatitis C virus.  Odd because hepatitis viruses typically infect the liver....making this an unusual disease.
http://www.ncbi.nlm.nih.gov/pubmed/17967838

Hepatitis C virus and Balo disease associations
http://www.ncbi.nlm.nih.gov/pubmed/24211061

Hepatitis c and brain tissue
http://www.ncbi.nlm.nih.gov/pubmed/20877724

Friday, April 4, 2014

Autoimmune cross-targeting in Goodpasture's syndrome?

Is Good pastures syndrome caused by cross-targeting?

The cross-targeting hypothesis is when 2 infections cause the immune system to target the same organ.  An outer infection and then a viral inner infection. Can we find 2 infections linked and do they indicate the same target?

tuberculosis and good pasture's syndrome
http://www.sjkdt.org/article.asp?issn=1319-2442;year=2013;volume=24;issue=4;spage=783;epage=788;aulast=Kashif

mycoplasmas as RA and good pasture's
http://www.indianjnephrol.org/article.asp?issn=0971-4065;year=2012;volume=22;issue=1;spage=45;epage=47;aulast=Sharma;type=0

fluA virus and good pasture's
http://annals.org/article.aspx?articleid=686082
influenza A is similar to the Spanish flu
how often does this flu infect the kidney?

Spanish flu and good pasture's
http://doctorrw.blogspot.com/2006/01/goodpasture-syndrome-and-spanish-flu.html 
Note that Goodpasture's name was associated with the disease because he found that the disease could still exist with only the viral infection present and that this puzzled him....he had proven other viral infections caused disease but this one was a puzzle. The virus did not always cause the disease alone yet could be found alone....we now know that it is autoimmune.

Do these viral infections replicate in the kidney? (swine flu has been found in people's pancreas and could be a trigger for type 1 diabetes)

Kidney and fluA
http://www.ncbi.nlm.nih.gov/pubmed/984071
http://www.ncbi.nlm.nih.gov/pubmed/12698331

not sure how Rhabdomyolysis will fit together with this: http://www.ncbi.nlm.nih.gov/pubmed/10515090

Newer blog post
http://angelabiggs.blogspot.com/2016/06/good-pastures-reexamined-as-autoimmune.html