This page is under construction...hypothesis not proven (links and references coming)
http://apt.rcpsych.org/content/15/5/364.full
(rare dementias)
Vascular dementia is extremely common and is caused by a lack of blood to the brain. These can occur after a stroke or from a vascular disease like Binswanger.
Alcoholic dementia causes Korsakoff where a person makes up information they can't remember and actually believe the fabrications.
Most of this blog post will be focused on the other forms of dementia and mental disease.
Frontal temporal lobe dementia:
Semantic dementia FTD: "the loss of words" Which has been strongly linked to viral infections
Behavioral variant FTD: which has the loss of social behavior, conduct, and impulse control. Which has been linked to Pick's disease where Tau proteins form Lewy bodies.
Progressive nonfluent aphasia FTD: which involves speech production, stuttering, and apraxia. This form has been linked to blood clots creating a stroke
The 4th type is connected with ALS, amyotrophic lateral sclerosis.
The confusing part is figuring out which diseases are, if any, autoimmune cross-targeting and which are just the virus causing dementia having used an infection to break the blood brain barrier only.
Autoimmune cross-targeting is when two infections tell the immune system to attack the same target. A virus marks the inside and the larger infection marks the outside. The overlapping immune system ends up having a stronger response and attacking the tissue/cell type not just the infection.
Only a few infections are know to have the ability to cross the blood brain barrier with ease leaving a "hole behind them" : strep, mycobacterias, candida, aspergillus, t.gondii, and sutterella/campylobacteria.
Group Aspergillus
Updated March 30 with Aflotoxin hypothesis and Tau protein. Aspergillus may explain how people with Asperger's has both Intestinal ganglioneurmatosis and Pick's disease associations. Both diseases have Tau protein. Aspergillus makes aflatoxin which may cause the tau. (I am guessing this because my ALS fungal suspect also makes an aflatoxin like compound and it too has tau found at the damaged nerves)
Frontotemporal dementia (pick's disase)http://www.ncbi.nlm.nih.gov/pubmed/24966676
Note that Pick's disease is associated with Tau plaques.
http://www.ncbi.nlm.nih.gov/pubmed/8960316
Group Herpes virus
For Behcet's disease the infection culprits are Streptococcus sanguinis and herpes simplex
Temporal lobes and Herpes simplex virus?
http://neuropathologyblog.blogspot.com/2009/02/why-does-herpes-virus-love-temporal.html
Herpes simplex viruses destroy the mitochondria of cells then ride the mitochondria down the axon in order to reach the next nerve to infect. (think of herpes zoster and shingles where it starts in the nerves of the spinal cord then travels outward following the nerve branching)
Alzheimer's is ultimately when the mitochondrias break and stop working. Mitochondrias can break more than one way which is why Tau is not always present.
group
Herpes zoster virus and the nerves radiating from the spinal cord and temporal lobe
Includes MS (with psoriasis triggering the autoimmune not eczema)
In order for the virus to reach the brain but must have something that opens the BBB? The mycobacteria connected with psoriasis can do this but not the staph connected to eczema.
Group
Hepatits C and ring formation of plaques
Incudes: Susac's disease and Balo's MS
Group
diacetyl group (too much fake butter/chardonnay ) In excess this damages the mitochondria
(not an infection so it can cross to the brain without help) or radicals damage
Includes Alzheimer's of early onset? Downsyndrome?
A note about amyloid plaques : I think they are due to the mitochondria not moving down the nerve root because diacetyl (or herpes virus ) has destroyed the mitochondria. I have a post where I suggest that app is a serine protease is involved with nerve growth. (neuroserpin would be the off switch) When the mitochondria does not move into place the nerve tries to ramp up growth.....maybe this is all guessing.
Amyloid plaques might be discarded calling cards.
Group
Mycobacterias
Includes:
parkinson's ( avian flu virus N5H1 cross-targeting?)
PANDAS (some are mycobacteria not strep crossed with flu H1N1?)
shy-drager ( cross-targeting suspect m.fortuitum but not proven)
Group
Strep
gluten ataxia, pandas, narcolepsy
gluten ataxia
http://www.ncbi.nlm.nih.gov/pubmed/15814071
Pandas (H1N1 or herpes zoster with the strep) note that different virus triggers are possible just like mycobacteria can replace strep. the target is more important than the infections
Pandas involves the midbrain region of the basal ganglia
http://www.slideshare.net/rossfinesmith1/pandas72
Remember from above H5N1 as a Parkinson's trigger was located in the midbrain dopamine neurons SNpc structure...which i suspect is the same in the pandas group. Specifically Pandas is the basal ganglia with strep and parkinson's is the Substantia Nigra with mycobacterias
Pineal Gland autoimmunity: narcolepsy
swine flu H1N1 / strep
http://www.ima.org.il/FilesUpload/IMAJ/0/95/47598.pdf
Group
Sutterella / Campylobacteria
Autism of the cerebellum (autoimmune cross targeting with a virus...measles there)
Guilian barre syndrome typically states in the periphery nerves but can on occasion cross to the cerebellum. sutterella is a relative and is easily confused with campylobacteria.
Guilian barre is the HHV4 cross-targeting with camypylobacteria
Group
Flu virus
Autism of the Frontal lobe
A fetus does not have a developed blood brain barrier so some will be at the mercy of the mother's immune system during pregnancy. RA can have antibodies against the frontal lobe which because of the underdeveloped BBB can reach the area. RA is considered associated with autism risk. The flu virus can also replicate in the frontal lobe of the brain. Mother's who have had the flu have been found to have higher rates of autism in newborn children.
Parkinson's flu H5n1
Narcolepsy flu H1n1 or vaccine for it and strep
http://healthysleep.med.harvard.edu/narcolepsy/what-is-narcolepsy/science-of-narcolepsy
Group
T. gondii
Includes schizophrenia and Rasussen's encephalitis
Schizophrenia is from t.gondii at the amygdala of the brain.
Rasussen's encephalitis has left hemisphere inflammation and the viral culprit that is under consideration causing the cross-targeting is the cytomegalvirus CMV and/or the epstein Barr virus. Biopsies currently being researched to determine which virus is present.
Infants with a similar disease have CMV.
http://www.ncbi.nlm.nih.gov/pubmed/23716471
LEWY BODIES: all plaques of the different proteins tend to get lumped into this description. Amyloid plaques, synuclien plaques, and tau plaques. The reasons they build up are different and more then one type can appear in one dementia. I dislike this term because it is confusing and prefer to focus on the specific type of plaques.
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