Dedicated in loving memory to my dear friend Sue.
Hypothesis: Cross-targeting autoimmunity occurs when 2 infections, one being a virus, infect the same target. This state causes the immune system to escalate the immune attack into autoimmunity because both the inside and the outside of the organ is marked as infected.
2 types of autoimmune liver disease and the overlapping syndromes:
http://www.ncbi.nlm.nih.gov/pubmed/19212308
3 types of autoimmune liver disease
http://www.ncbi.nlm.nih.gov/pubmed/16989180
1.Autoimmune Hepatitis (AIH) and celiac disease
http://www.ncbi.nlm.nih.gov/pubmed/15645466
note that I have celiac disease associated with one form of e.coli. E.coli make bilirubin when it breaks down RBC which could produce antibodies against the liver who also makes bilirubin. I am suggesting that someone out there look for these anti-bilirubin antibodies in these types of cases.
2.Primary (Autoimmune) Sclerosing Cholangitis
PSC with IBS
If the IBS is not crohn's or ulcerative colitis is it microscopic colitis? which could be fungal?
http://angelabiggs.blogspot.com/2013/05/microscopic-colitis.html
If we divide these into separate types:
primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC)
with PBC found more in women and being the fungal type then what causes PSC?
PSC and RA? mycoplasmas and cancer?
http://www.ncbi.nlm.nih.gov/pubmed/23868731 (PSC and RA )
http://www.ncbi.nlm.nih.gov/pubmed/24637212 (liver, mycoplasma, cancer)
RA and mycoplasmas (old post)
http://angelabiggs.blogspot.com/2013/04/lupus-and-ra-leukemia-and-mycoplasmas.html
I have a strong overlap with mycoplasmas and autoimmune hemolitic anemia
http://angelabiggs.blogspot.com/2014/06/autoimmune-hemolytic-anemia-and-cross.html
The obvious viral triggers causing the the cross-targeting are hepatitis A, B, and C. They do not not cause the autoimmune disease alone. Only if an infection or anti-bodies preexist against the liver.
Hypothesis: Cross-targeting autoimmunity occurs when 2 infections, one being a virus, infect the same target. This state causes the immune system to escalate the immune attack into autoimmunity because both the inside and the outside of the organ is marked as infected.
2 types of autoimmune liver disease and the overlapping syndromes:
http://www.ncbi.nlm.nih.gov/pubmed/19212308
3 types of autoimmune liver disease
http://www.ncbi.nlm.nih.gov/pubmed/16989180
1.Autoimmune Hepatitis (AIH) and celiac disease
http://www.ncbi.nlm.nih.gov/pubmed/15645466
note that I have celiac disease associated with one form of e.coli. E.coli make bilirubin when it breaks down RBC which could produce antibodies against the liver who also makes bilirubin. I am suggesting that someone out there look for these anti-bilirubin antibodies in these types of cases.
2.Primary (Autoimmune) Sclerosing Cholangitis
PSC with IBS
If the IBS is not crohn's or ulcerative colitis is it microscopic colitis? which could be fungal?
http://angelabiggs.blogspot.com/2013/05/microscopic-colitis.html
If we divide these into separate types:
primary biliary cirrhosis (PBC), and primary sclerosing cholangitis (PSC)
with PBC found more in women and being the fungal type then what causes PSC?
PSC and RA? mycoplasmas and cancer?
http://www.ncbi.nlm.nih.gov/pubmed/23868731 (PSC and RA )
http://www.ncbi.nlm.nih.gov/pubmed/24637212 (liver, mycoplasma, cancer)
RA and mycoplasmas (old post)
http://angelabiggs.blogspot.com/2013/04/lupus-and-ra-leukemia-and-mycoplasmas.html
I have a strong overlap with mycoplasmas and autoimmune hemolitic anemia
http://angelabiggs.blogspot.com/2014/06/autoimmune-hemolytic-anemia-and-cross.html
The obvious viral triggers causing the the cross-targeting are hepatitis A, B, and C. They do not not cause the autoimmune disease alone. Only if an infection or anti-bodies preexist against the liver.
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