Monday, July 7, 2014

Does cross-targeting cause the autoimmune disease Kinsbourne syndrome or Opsoclonus Myoclonus Syndrome (OMS)?

Hypothesis: Cross-targeting autoimmunity occurs when 2 infections, one being a virus, infect the same target.  This state causes the immune system to escalate the immune attack into autoimmunity because both the inside and the outside of the organ is marked as infected.


Kinsbourne syndrome or Opsoclonus Myoclonus Syndrome (OMS)

http://www.ncbi.nlm.nih.gov/pubmed/24995204

west nile virus
http://www.ncbi.nlm.nih.gov/pubmed/24968889
http://www.ncbi.nlm.nih.gov/pubmed/16966514
http://www.ncbi.nlm.nih.gov/pubmed/24987503
http://www.ncbi.nlm.nih.gov/pubmed/24688189

What organ is the target? the nerves?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3528292

(west nile and polio like paralysis ? http://www.ncbi.nlm.nih.gov/pubmed/17168167  http://www.ncbi.nlm.nih.gov/pubmed/12929189)

Strep A
http://www.ncbi.nlm.nih.gov/pubmed/17414405
http://www.ncbi.nlm.nih.gov/pubmed/12886983
http://www.ncbi.nlm.nih.gov/pubmed/17486621

Strep would break the blood brain barrier letting the virus through or can the virus get there alone? Kinsbourne is an autoimmune disease attack on brain cells (neurons)...so is it the cross-targeting of strep A and west nile virus?

Adrenal glands and west nile  virus
http://www.ncbi.nlm.nih.gov/pubmed/16896857
http://www.sart.org/uploadedFiles/ASRM_Content/News_and_Publications/Practice_Guidelines/Position_Statements/ASRM_SART_position%281%29.pdf

Neuroblastoma is associated with
Opsoclonus Myoclonus Syndrome (OMS) and with starting in the adrenal glands. Does the west nile virus play a role in the development of this form of cancer?

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