If autism is caused by autoimmune cross-targeting and the target is the brain, how do the antibodies get past the blood brain barrier? note that this is not always the case because antibodies against the brain have been found in pregnant mothers crossing the blood brain barrier. I am just trying to figure out if it is just antibody driven as an autoimmune disease or if the infection can move there.
Strep and E.coli infections are able to get past the blood brain barrier and the intestinal barrier.
Invasion of the brain by strep by receptor-ligand
http://www.ncbi.nlm.nih.gov/pubmed/9393798
Invasion of brain by e.coli by receptor-ligand
http://www.ncbi.nlm.nih.gov/pubmed/10496943
Mycobacteria can also break the blood-brain barrier causing a hole by cytoskeleton alterations but it does not use a receptor to get into the host cell. (this reference is a review paper by Kim)
http://www.ncbi.nlm.nih.gov/pubmed/16542662
Here is just Kim's table of what can transverse the blood brain barrier:
http://www.nature.com/nrmicro/journal/v6/n8/fig_tab/nrmicro1952_T1.html
Does sutterella have the ability to cross in the same way? by receptor- ligands? It has been found in brain abcesses.....does it know how to cross the barriers?
I am looking for this "ligand" in the genetic code but it doesn't even appear to be elucidated in Strep. They think it is choline related because with out choline virulence is lost.
http://www.ncbi.nlm.nih.gov/pubmed/19433549
Choline immediately makes me think of neurons.....how foreboding.
Once sutterella is infecting the neurons would a measles shot cause them to be targeted? The cross-targeting would cause the brain cells to be attacked by the immune system seeing not just the infections as the issue but the brain's neurons?
This is based on a ton of assumptions. First that sutterella is a culprit because it is found in half of autistic kids indicating it's involvement.
This page is still under construction.
I am wondering if:
Classic autism is the maternal antibody driven kind
Childhood disintegrative disorder is the sutterella driven kind.
Strep and E.coli infections are able to get past the blood brain barrier and the intestinal barrier.
Invasion of the brain by strep by receptor-ligand
http://www.ncbi.nlm.nih.gov/pubmed/9393798
Invasion of brain by e.coli by receptor-ligand
http://www.ncbi.nlm.nih.gov/pubmed/10496943
Mycobacteria can also break the blood-brain barrier causing a hole by cytoskeleton alterations but it does not use a receptor to get into the host cell. (this reference is a review paper by Kim)
http://www.ncbi.nlm.nih.gov/pubmed/16542662
Here is just Kim's table of what can transverse the blood brain barrier:
http://www.nature.com/nrmicro/journal/v6/n8/fig_tab/nrmicro1952_T1.html
Does sutterella have the ability to cross in the same way? by receptor- ligands? It has been found in brain abcesses.....does it know how to cross the barriers?
I am looking for this "ligand" in the genetic code but it doesn't even appear to be elucidated in Strep. They think it is choline related because with out choline virulence is lost.
http://www.ncbi.nlm.nih.gov/pubmed/19433549
Choline immediately makes me think of neurons.....how foreboding.
Once sutterella is infecting the neurons would a measles shot cause them to be targeted? The cross-targeting would cause the brain cells to be attacked by the immune system seeing not just the infections as the issue but the brain's neurons?
This is based on a ton of assumptions. First that sutterella is a culprit because it is found in half of autistic kids indicating it's involvement.
This page is still under construction.
I am wondering if:
Classic autism is the maternal antibody driven kind
Childhood disintegrative disorder is the sutterella driven kind.
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