Monday, February 24, 2014

Is scleroderma an autoimmune disease caused by cross-targeting?

Cross-targeting of the immune system triggers autoimmunity by layering immune system attacks onto one target.  One viral marking the inside of the target and one visible marking the outside of the target...like a fungus or bacteria.

Epstein barr virus and scleroderma
http://www.ncbi.nlm.nih.gov/pubmed/24164500
http://www.ncbi.nlm.nih.gov/pubmed/24129067

Cryptococcus neoformans and scleroderma
http://www.ncbi.nlm.nih.gov/pubmed/23496879
http://www.ncbi.nlm.nih.gov/pubmed/22381693
this is the fungus found in the droppings of wild birds

Crest syndrome (connective tissue is the target?)
http://en.wikipedia.org/wiki/CREST_syndrome
http://www.ncbi.nlm.nih.gov/pubmed/21956352

What would cause the hardened skin? cryptococcus secretes Mucopolysaccharidoses

https://books.google.com/books?id=eLHQAgAAQBAJ&pg=PA807&lpg=PA807&dq=Cryptococcus+secretes&source=bl&ots=LTAfTTSaQg&sig=5199n_brNSVOVS0e66h6Q_PM7Bs&hl=en&sa=X&ved=0ahUKEwiax62J24TNAhVVO1IKHZ4sDOcQ6AEITjAG#v=onepage&q=Cryptococcus%20secretes&f=false

Mucopolysaccharides are also called glucosaminoglycans and are also found in the fluids that lubricate joints. Glucosaminoglycans are major components of connective tissue like tendons.  Glucosaminoglycans: dermatan sulfate and chondroitin sulfate associate with the collagen of the tendon.

Glucosaminoglycans are increased in scleroderma
http://www.sciencedirect.com/science/article/pii/S0022202X15481126

I had previously connected sjogern's to candida infections and Hashimoto's thyroid.
Here is a personal post from someone who has hashimoto's with scleroderma. Do they have cryptococcus?
http://www.inspire.com/groups/autoimmune-diseases/discussion/hashimotos-rheumatoid-arthritis-scleroderma-i/

I am also looking at nickel allergy and it's relationship to crytococcosis:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3697809/
allergy and scleroderma
http://www.inspire.com/groups/scleroderma-foundation/discussion/nickle-exposure-and-scleroderma/

note that cyrptococcus gatti infects the lungs, the skin, the lymph nodes, bones, and joints
while the epstein barr virus (mono) infects primarily lymphatic cells....this could the the area of overlap.

here are posts of people with scleroderma and swollen lymph nodes
http://treato.com/Scleroderma,Swollen+Lymph+Nodes/?a=s 

the lymphatic system and scleroderma
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2829123/

Epstein barr can infect any cell with an estrogen receptor so it could be infecting the connective tissue directly too

Tendons and estrogen receptors
http://www.ncbi.nlm.nih.gov/pubmed/20073985

Does this make sense to anyone else out there? Can anyone see what i see?





2 comments:

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  2. Thanks for sharing such wonderful knowledge! Natural Treatment for Scleroderma skin disease and building a strong immune system.

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