Friday, February 14, 2014

Myasthenia Gravis Autoimmune disease starts in the thymus

This is an autoimmunity hypothesis for Myasthenia gravis:

Cross-targeting of the immune system triggers autoimmunity by layering immune system attacks on one target. In this case an infection of the thymus overlaps a viral infection of the thymus.  Raising the level of tlr-4 too high?

Possible viral triggers are:

West nile virus and MG
http://www.ncbi.nlm.nih.gov/pubmed/23559196
http://cdn.f1000.com/posters/docs/250566628

epstein-barr and MG
http://www.ncbi.nlm.nih.gov/pubmed/21961056 
http://www.ncbi.nlm.nih.gov/pubmed/20517934

coxsackie and MG?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514990/

Note these viral infections must infect the target or generate antibodies toward the target.

MG has been associated with RA, lupus and type 1 diabetes so I am looking into mycoplasmas as the infection which may have taken up residence in the thymus (non viral)

specifically M.fermentans
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC415086/

and C. pneumoniae (detected in thymus)
http://www.ncbi.nlm.nih.gov/pubmed/9593019

Tlr-4 and MG
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1603452/

note that this is slightly different then Graves.

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