This is an autoimmunity hypothesis for Myasthenia gravis:
Cross-targeting of the immune system triggers autoimmunity by layering immune system attacks on one target. In this case an infection of the thymus overlaps a viral infection of the thymus. Raising the level of tlr-4 too high?
Possible viral triggers are:
West nile virus and MG
http://www.ncbi.nlm.nih.gov/pubmed/23559196
http://cdn.f1000.com/posters/docs/250566628
epstein-barr and MG
http://www.ncbi.nlm.nih.gov/pubmed/21961056
http://www.ncbi.nlm.nih.gov/pubmed/20517934
coxsackie and MG?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514990/
Note these viral infections must infect the target or generate antibodies toward the target.
MG has been associated with RA, lupus and type 1 diabetes so I am looking into mycoplasmas as the infection which may have taken up residence in the thymus (non viral)
specifically M.fermentans
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC415086/
and C. pneumoniae (detected in thymus)
http://www.ncbi.nlm.nih.gov/pubmed/9593019
Tlr-4 and MG
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1603452/
note that this is slightly different then Graves.
Cross-targeting of the immune system triggers autoimmunity by layering immune system attacks on one target. In this case an infection of the thymus overlaps a viral infection of the thymus. Raising the level of tlr-4 too high?
Possible viral triggers are:
West nile virus and MG
http://www.ncbi.nlm.nih.gov/pubmed/23559196
http://cdn.f1000.com/posters/docs/250566628
epstein-barr and MG
http://www.ncbi.nlm.nih.gov/pubmed/21961056
http://www.ncbi.nlm.nih.gov/pubmed/20517934
coxsackie and MG?
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514990/
Note these viral infections must infect the target or generate antibodies toward the target.
MG has been associated with RA, lupus and type 1 diabetes so I am looking into mycoplasmas as the infection which may have taken up residence in the thymus (non viral)
specifically M.fermentans
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC415086/
and C. pneumoniae (detected in thymus)
http://www.ncbi.nlm.nih.gov/pubmed/9593019
Tlr-4 and MG
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1603452/
note that this is slightly different then Graves.
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