Monday, July 1, 2019

Behcet's disease is autoimmune cross-targeting of strep and HSV1 update

Behcet's disease is autoimmune cross-targeting of strep and HSV1

Behcets has anti-cardiolipin and is associated with strep
http://angelabiggs.blogspot.com/2013/04/behcets-disease.html

Behcets and mitochondria polymorphisms
https://acrabstracts.org/abstract/genetic-association-of-mitochondrial-dna-polymorphisms-with-behcets-disease-in-a-korean-population/

HLA-B5, Behcets and autoimmune disease
https://acrabstracts.org/abstract/hla-b51-and-possible-associated-autoimmune-disorders-other-than-behcets-disease-a-retrospective-cohort-study/

HLA-B is the t cell mailbox for mitochondrial infections which HSV-1 is

Behcet's and herpes simplex 1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857840/

erythema nodosum and behcets
https://www.ncbi.nlm.nih.gov/pubmed/22504656

TLR9 and behcet's
https://www.ncbi.nlm.nih.gov/pubmed/23237868

TLR9 is the butterfly net for mitochondria infections. When triggered it causes the expression of HLA-b and IFNalpha

Behcets has anti-cardiolipin and is associated with strep
http://angelabiggs.blogspot.com/2013/04/behcets-disease.html

Behcet's Disease is it a cross-targeting autoimmune disease?



The autoimmune hypothesis pattern: an infection first inducing antibodies followed by a viral infection which causes cross-targeting thus triggering the immune system to attack causing autoimmune disease. 

For Behcet's disease the infection culprits are Streptococcus sanguinis and herpes simplex (mouth ulcers)

http://www.ncbi.nlm.nih.gov/pubmed/23137016
http://www.ncbi.nlm.nih.gov/pubmed/18693149 
http://www.ncbi.nlm.nih.gov/pubmed/21052488
http://www.ncbi.nlm.nih.gov/pubmed/22204815
http://www.ncbi.nlm.nih.gov/pubmed/22766172


I found a strange overlap with MS and Behcet's.
http://www.ncbi.nlm.nih.gov/pubmed/12645628 

For MS I have as psoriasis or eczema with herpes zoster triggering the autoimmune disease.    

Could this be an entirely different type of MS? Where the strep has opened the blood brain barrier and the herpes virus is there?  Is this actually a form of Alzheimer's?   Where the herpes simplex virus is destroying the mitochondria?  Or do I need to become much more specific with the herpes viruses? That could be the case.  

Balo was/is a different type of MS where the virus is a hepatitis C virus and causing the ring shaped lesions. Balo is really a distinct autoimmune disease from MS. 

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