Friday, July 12, 2019

IgG2, GSDMD, and cytosol infections

Hypothesis: GSDM pores are windows for eosinophils

Does the GSDM pore hold the infection inside of cells at the surface and allow eosinphils to phagocytosis infected cells through antibody binding at the pore?

il-13 and IgG2 production by B cells
https://www.ncbi.nlm.nih.gov/pubmed/10415009

High IgG2 and Cryptococcus neoformans 
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1828574/

Cryptococcus neoformans inside macrophages
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5127716/

il-13 and C. neoformans
https://www.ncbi.nlm.nih.gov/pubmed/17911623

Does the GSDM pore hold the infection inside of cells at the surface and allow eosinphils to phagocytosis infected cells through antibody binding at the pore?

IgE at the skin's IGF-1  with the GSDMA pore
IgA GH with GSDMB
IgG1,  insulin with GSDMC

IgG2 with GSDMD...all areas involving cytosol infections

High IgG2 and Plasmodium
https://iai.asm.org/content/iai/68/3/1252.full.pdf

Plasmodium are inside erythrocytes
https://academic.oup.com/femsre/article/40/5/701/2198099

eosinophils and plasmodium (malaria parasite)

mycobacteria and cytosol
https://academic.oup.com/femsre/article/43/4/341/5420823

mycobacteria and IgG2
https://gh.bmj.com/content/4/Suppl_3/A31.2

mycobacteria and GSDMD
https://www.biorxiv.org/content/biorxiv/early/2019/02/17/514125.full.pdf

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