Hypothesis: il-27 cytokine is secreted by B cells when there is a viral infection or cancer damage involving the cytosol of cells.
p53 and il-27
http://clincancerres.aacrjournals.org/content/clincanres/early/2016/05/27/1078-0432.CCR-15-2052.full.pdf
Is il-27 involved with DNA damage?
melanoma and il-27
https://www.ncbi.nlm.nih.gov/pubmed/18453571
melanoma is a cancer caused by DNA damage (from sun exposure)
DNA damage and the cytosolic sensors
http://jem.rupress.org/content/215/5/1287
B cells major source of il-27
https://www.jimmunol.org/content/200/1_Supplement/107.5
B cells produce IgG2a (class switch) after il-27
https://www.jimmunol.org/content/173/4/2479.long?utm_source=TrendMD&utm_medium=cpc&utm_campaign=J_Immunol_TrendMD_0
IgG2a against reoviruses and parasites
https://academic.oup.com/intimm/article/12/2/223/652665
il-27 attracts myeloid dendritic cells to the lymph
https://www.jimmunol.org/content/192/6/2634
previous hypothesis:
myeloid dendritic cells are involved with infections of the cytosol
plasmacytoid dendritic cells are involved with infection of the mitochondria/ nucleus
il-27 not il-35 suppresses gm-csf
https://www.nature.com/articles/s41598-017-16702-w
GM-csf is involved with vacuole bacteria and TH17 triggering
GM-csf exposed Basophil's produce il-6 and trigger th17
https://www.nature.com/articles/srep41744
GM-csf exposed mDendritic make il-23
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297527/
As a cytosol infection TH1 is involved
https://www.nature.com/articles/7310017?error=server_error
il-27 is saying it is in the cytosol..what ever it is...not a bacteria hiding in the cytosol or in a virus in the nucleus or mitochondria.
Furthermore
il-27 suppressed il-5 and il-13 from TH2 cells which is used against parasites in the cytosol. Which means il-27 could be strictly a cytokine for viruses or for DNA from cancer in the cytosol?
https://www.jimmunol.org/content/179/7/4415
When does the B cell decide to make il-27? Does the T follicular cell recognize it as DNA and signal back to the B cell?
p53 and il-27
http://clincancerres.aacrjournals.org/content/clincanres/early/2016/05/27/1078-0432.CCR-15-2052.full.pdf
Is il-27 involved with DNA damage?
melanoma and il-27
https://www.ncbi.nlm.nih.gov/pubmed/18453571
melanoma is a cancer caused by DNA damage (from sun exposure)
DNA damage and the cytosolic sensors
http://jem.rupress.org/content/215/5/1287
B cells major source of il-27
https://www.jimmunol.org/content/200/1_Supplement/107.5
B cells produce IgG2a (class switch) after il-27
https://www.jimmunol.org/content/173/4/2479.long?utm_source=TrendMD&utm_medium=cpc&utm_campaign=J_Immunol_TrendMD_0
IgG2a against reoviruses and parasites
https://academic.oup.com/intimm/article/12/2/223/652665
il-27 attracts myeloid dendritic cells to the lymph
https://www.jimmunol.org/content/192/6/2634
previous hypothesis:
myeloid dendritic cells are involved with infections of the cytosol
plasmacytoid dendritic cells are involved with infection of the mitochondria/ nucleus
il-27 not il-35 suppresses gm-csf
https://www.nature.com/articles/s41598-017-16702-w
GM-csf is involved with vacuole bacteria and TH17 triggering
GM-csf exposed Basophil's produce il-6 and trigger th17
https://www.nature.com/articles/srep41744
GM-csf exposed mDendritic make il-23
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297527/
As a cytosol infection TH1 is involved
https://www.nature.com/articles/7310017?error=server_error
il-27 is saying it is in the cytosol..what ever it is...not a bacteria hiding in the cytosol or in a virus in the nucleus or mitochondria.
Furthermore
il-27 suppressed il-5 and il-13 from TH2 cells which is used against parasites in the cytosol. Which means il-27 could be strictly a cytokine for viruses or for DNA from cancer in the cytosol?
https://www.jimmunol.org/content/179/7/4415
When does the B cell decide to make il-27? Does the T follicular cell recognize it as DNA and signal back to the B cell?
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