T cells
Central memory cells : lymph : TCR weak high number of interactions: medium life
Effector cells: circulating: TCR strong: short life
Tissue resident memory cells: tissue: il-7 : long life
memory t cells and il-7
https://www.ncbi.nlm.nih.gov/pubmed/28912605
TCR and il-7
http://www.jimmunol.org/content/169/7/3752
Does il-7 replace the activation of the TCR in the B zone and over time creates the T memory cells with long life?
B cells
Central memory : lymph : BCR weak high number of interactions : medium life
Effector: circulating: BCR strong (plasma to bone marrow): short life
Spleen resident memory in red pulp : spleen : il-6? : long life
Megakaryocytes produce il-6
we already know that b cells will produce the IgM antibody with just il-6 and no BCR activation
so is this how high affinity B memory cells are made? il-6 exposure in the red pulp ?
Note that T cells' TCR memory is involved with inner antigens: TH the cytosol and Tc the mitochondria/nucleus while Bcells' BCR and memory are involved with outer antigens.
Central memory cells : lymph : TCR weak high number of interactions: medium life
Effector cells: circulating: TCR strong: short life
Tissue resident memory cells: tissue: il-7 : long life
memory t cells and il-7
https://www.ncbi.nlm.nih.gov/pubmed/28912605
TCR and il-7
http://www.jimmunol.org/content/169/7/3752
Does il-7 replace the activation of the TCR in the B zone and over time creates the T memory cells with long life?
B cells
Central memory : lymph : BCR weak high number of interactions : medium life
Effector: circulating: BCR strong (plasma to bone marrow): short life
Spleen resident memory in red pulp : spleen : il-6? : long life
Megakaryocytes produce il-6
we already know that b cells will produce the IgM antibody with just il-6 and no BCR activation
so is this how high affinity B memory cells are made? il-6 exposure in the red pulp ?
Note that T cells' TCR memory is involved with inner antigens: TH the cytosol and Tc the mitochondria/nucleus while Bcells' BCR and memory are involved with outer antigens.
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