Saturday, July 7, 2018

Comparing T and B memory cells: is this possible?

T cells

Central memory cells : lymph : TCR weak high number of interactions: medium life

Effector cells: circulating: TCR strong: short life

Tissue resident memory cells: tissue: il-7 : long life

memory t cells and il-7
https://www.ncbi.nlm.nih.gov/pubmed/28912605

TCR and il-7
http://www.jimmunol.org/content/169/7/3752

Does il-7 replace the activation of the TCR in the B zone and over time creates the T memory cells with long life?

B cells

Central memory : lymph : BCR weak high number of interactions : medium life

Effector: circulating: BCR strong (plasma to bone marrow): short life

Spleen resident memory in red pulp  : spleen : il-6? : long life

Megakaryocytes produce il-6

we already know that b cells will produce the IgM antibody with just il-6 and no BCR activation

so is this how high affinity B memory cells are made? il-6 exposure in the red pulp ?


Note that T cells' TCR memory is involved with inner antigens: TH the cytosol and Tc the mitochondria/nucleus while Bcells' BCR and memory are involved with outer antigens.






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