The T zone, the B zone, and antigen memory.

The antigens of the inside of our cells involves both the T zone and the B zone using the T cell's TCR  while outer antigens involve only the B zone and the BCR.
When the receptor binding is weak but multiple cycles have occurred Central memory cells are made. When the receptor bind is strong effector memory cells are made.

Again multiple interactions with weak receptor binding produces central memory cells. If the infection changes slightly within the year the immune system will quickly be ready.  This type of memory is not kept full term because it is not specific. 

Activated Th1 cells with B cells produces IgG2. These antibodies are against the cytosol antigens.

Activated cd8 Tc cells with B cells produce IgG3. These antibodies are against the nuclear and mitochondrial antigens. 

The TFH with Bcells produces different antibodies based on the hormone present. The spleen sees high levels of insulin because of the pancreas thus produces IgG1.  The peyer patches B cells see growth hormone and produce IgA antibodies. The skin lymph see insulin-like growth factor-1 and produce IgE.