Thursday, June 21, 2018

Co-stimulatory molecules and B7 molecules: corrected (i had them mixed up)


Maybe? But as TCR activated in the Tc the pd-1 expressed less so the activation increases? 
Note that some tumors with could be started by viruses express b7-h1 and MHC1 like pd.





FDC induced APC characteristics from B cells
https://link.springer.com/chapter/10.1007/978-1-4615-1971-3_67

It appears that cells that interact with the follicular dendritic cells FDC have B7-2.  What is the receptor on FDC for B7-2?

B7-DC induces IFNgamma (cytosol antigens: m. dentritic )
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2193370/

B7-H1 induces il-10 (mitochondria/ nuclear antigens p. dendritic )
https://www.ncbi.nlm.nih.gov/pubmed/21830424

B7-1 and B7-2 both induce il-4 (outside antigens: langerhans)
https://www.ncbi.nlm.nih.gov/pubmed/7577797

when antigens are in the mitochondria/nuclear area

PD-1 on CD8
https://www.ncbi.nlm.nih.gov/pubmed/29654146

PDL-1 (B7-H1)  binding PD1 converts TH1 into T regulatory
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235958/

B7-H1 and antigen responses not cytotoxic responses
http://www.bloodjournal.org/content/97/6/1809?sso-checked=true


Which brings the possibility:




CTLA4 blocks the outer antigen pathways but not the inner antigen pathways?

B7-1 costimulates cd8 cells but not B7-2
https://www.ncbi.nlm.nih.gov/pubmed/8543795

B7-1 as a ligand for pd-1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2707944/

B7-2 appears on Langerhans and marginal zone B cells that bring antigens to the follicular dendritic cell.


The langerhans use the conduit.  Reticular cells produce CXCL13 which attracts B and T cells. These cells may also become FDC which holds the antigen for the B cells.



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