Elucidating the function of natural Treg and inducible Treg

Natural Treg aka Thymus Treg are the T regulatory cells responsible for focusing the immune system on one zone.

3 Zones are involved in infections:

1.Outside of host cells which involves a burst of il-4 from basophils trigger TH2 reaction pathways

2. Just inside the cytosol of host cells which involves TH1 and a burst of il-2 and CTLs kill using FAS.

3. Then inside of the organelles of cells (the mitochondria or the nucleus)  where TGF-B1 levels are high  from platelets and CTLs kill infected cells with mhc1.

Natural Treg have receptors for each of these: il-2r (cd25),  il-4r, and a TGF-B1 receptor so that when Treg are circulating in the bloodstream they can immediately help focus the reactions.

When natural Treg see one pathway started they secrete cytokines to shut down the other 2 pathways.

il-4 bound and it secretes il-10 which stops TH1 and il-35 which stops CTL or cd8 reactions

il-2 bound and it secretes TGF-B1 which stops TH2 pathways and il-35 which stops CD8 reactions

TGF-B1 bound and it secretes TGF-B1 which stops TH2 pathways and il-10 which stops TH1 pathways.

Inducible Treg aka Adaptive Treg stop the immune reactions when the infection is killed off and gone.

They are specialized and secrete to stop the ongoing pathway used to kill the infection.

Tr1 secretes il-10 stopping TH1
TH3 secretes TGF-B1 stopping TH2
iTr35 secretes il-35 which inhibits and stops CTL

RANTES which is also involved in producing memory cells at the end of an infection may recruit and differentiate the iTregs.

Rantes and iTreg
https://onlinelibrary.wiley.com/doi/pdf/10.1111/aji.12013

nTreg get a TGF-B1 burst from platelets?

Some viral infections trigger platelet activation. Platelets have tlr7 and tlr9 which I previously linked to nuclear and mitochondrial antigens. Do Platelets release most of the TGF-B1?

platelets and TGF-B1
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271718/

Herpes and Platelets
https://www.ncbi.nlm.nih.gov/pubmed/6307229
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270245/
https://www.ncbi.nlm.nih.gov/pubmed/566472

https://www.researchgate.net/publication/228341940_Acyclovir-Induced_Immune_Thrombocytopenia_in_a_Patient_with_Herpes_Zoster_of_the_Trigeminal_Nerve

platelets and tlr7/ tlr9
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118487/
http://jcb.rupress.org/content/198/4/561
https://www.researchgate.net/publication/261800204_Platelet-TLR7_mediates_host_survival_and_platelet_count_during_viral_infection_in_the_absence_of_platelet-dependent_thrombosis