Saturday, July 14, 2018

Somatic hypermutation: prediction that IgG2 like IgG3 has very little



CD8 cells not found in GC
http://clincancerres.aacrjournals.org/content/23/1/250

IgG3 has very little somatic hypermutation
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5413556/


FDC follicular dendritic cell
mD myeloid dendritic cell
pD plasmacytoid dendritic cell

Dendritic cells are " pacmans " of the immune system picking up antigens  (related to macrophages)

MHC are mailboxes for showing antigens to T cells

The CD4  and CD8 are clips that hold the mailbox while the TCR t cell receptor looks at the antigen.

Note that T cells are educated in the thymus to know inside self antigens. While the B cells and the BCR b cell receptor is educated to know outside self antigens.  The BCR is the reason for somatic hypermutation. BCRs are literally worn antibodies.  The somatic hypermutation improves the binding and creates a strong binding antibody.


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