Wednesday, January 31, 2018

Sorting IgG antibodies: Does IgG3 match up with organelle infections while IgG2a appears alone (no IgG2b) with cytosol infections?

IgG1 is the dominant antibody with high FC receptor affinity

IgG2a and IgG2b are strong complement antibodies (mice, humans only have IgG2)

IgG2c Fc receptor "clean up antibody" only macrophage pick up not complement

IgG3 is seen less often with some viral infections

Flu a cytosol virus triggers IgG1 and IgG2a
http://cvi.asm.org/content/13/9/981.full

Herpes virus, organelle virus, triggers IgG1 and IgG3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC271254/

strep a visible bacteria : IgG1, IgG2a, IgG2b
https://www.ncbi.nlm.nih.gov/pubmed/15232177

IgG2c against amyloid (self protein outside of the cell)
https://www.ncbi.nlm.nih.gov/pubmed/12565127

IgG2c against tumors
http://www.jimmunol.org/content/jimmunol/172/2/929.full.pdf

IgG2c does not activate complement
https://www.researchgate.net/post/how_different_are_the_functions_of_IgG2a_and_IgG2c

campylobacteria is hidden in the host's cytosol (bacteria in vacuoles) IgG1 and IgG2a
https://www.sciencedirect.com/science/article/pii/S1877282X15000089

HPV, organelle (nucleus) virus, triggers IgG1 and IgG3
https://www.ncbi.nlm.nih.gov/pubmed/24058629

antibody review
http://absoluteantibody.com/antibody-resources/antibody-overview/antibody-isotypes-subtypes/

note IgG4 appears with autoimmunity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897107/

IgG4 inhibits compliment
https://www.sciencedirect.com/science/article/pii/B9780323069472100094

IgG2 triggers complement

IgG4 and IgG2 have the same non classical disulfide bond structure
https://www.researchgate.net/publication/221825860_Disulfide_bond_structures_of_IgG_molecules

Disulfide bonds in IgG
IgG1 has 2
IgG2 has 4
IgG3 has 11

why does IgG3 have 11 disulfide bonds? is it because it interacts with DNA?

DNA and disulfide bonds
https://www.sciencedirect.com/science/article/pii/S0014579399000599

IgG3 and anti-DNA

https://books.google.com/books?id=tj9JR3IITy8C&pg=PA455&lpg=PA455&dq=IgG3+anti+DNA&source=bl&ots=nnbaHQAhrL&sig=P7Vin_57g7Wqt1QwZZ4C4WNbqrc&hl=en&sa=X&ved=0ahUKEwjt4rO7hYPZAhUG02MKHVzPCmY4ChDoAQg2MAM#v=onepage&q=IgG3%20anti%20DNA&f=false


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