IgG1 is the dominant antibody with high FC receptor affinity
IgG2a and IgG2b are strong complement antibodies (mice, humans only have IgG2)
IgG2c Fc receptor "clean up antibody" only macrophage pick up not complement
IgG3 is seen less often with some viral infections
Flu a cytosol virus triggers IgG1 and IgG2a
http://cvi.asm.org/content/13/9/981.full
Herpes virus, organelle virus, triggers IgG1 and IgG3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC271254/
strep a visible bacteria : IgG1, IgG2a, IgG2b
https://www.ncbi.nlm.nih.gov/pubmed/15232177
IgG2c against amyloid (self protein outside of the cell)
https://www.ncbi.nlm.nih.gov/pubmed/12565127
IgG2c against tumors
http://www.jimmunol.org/content/jimmunol/172/2/929.full.pdf
IgG2c does not activate complement
https://www.researchgate.net/post/how_different_are_the_functions_of_IgG2a_and_IgG2c
campylobacteria is hidden in the host's cytosol (bacteria in vacuoles) IgG1 and IgG2a
https://www.sciencedirect.com/science/article/pii/S1877282X15000089
HPV, organelle (nucleus) virus, triggers IgG1 and IgG3
https://www.ncbi.nlm.nih.gov/pubmed/24058629
antibody review
http://absoluteantibody.com/antibody-resources/antibody-overview/antibody-isotypes-subtypes/
note IgG4 appears with autoimmunity
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897107/
IgG4 inhibits compliment
https://www.sciencedirect.com/science/article/pii/B9780323069472100094
IgG2 triggers complement
IgG4 and IgG2 have the same non classical disulfide bond structure
https://www.researchgate.net/publication/221825860_Disulfide_bond_structures_of_IgG_molecules
Disulfide bonds in IgG
IgG1 has 2
IgG2 has 4
IgG3 has 11
why does IgG3 have 11 disulfide bonds? is it because it interacts with DNA?
DNA and disulfide bonds
https://www.sciencedirect.com/science/article/pii/S0014579399000599
IgG3 and anti-DNA
https://books.google.com/books?id=tj9JR3IITy8C&pg=PA455&lpg=PA455&dq=IgG3+anti+DNA&source=bl&ots=nnbaHQAhrL&sig=P7Vin_57g7Wqt1QwZZ4C4WNbqrc&hl=en&sa=X&ved=0ahUKEwjt4rO7hYPZAhUG02MKHVzPCmY4ChDoAQg2MAM#v=onepage&q=IgG3%20anti%20DNA&f=false
IgG2a and IgG2b are strong complement antibodies (mice, humans only have IgG2)
IgG2c Fc receptor "clean up antibody" only macrophage pick up not complement
IgG3 is seen less often with some viral infections
Flu a cytosol virus triggers IgG1 and IgG2a
http://cvi.asm.org/content/13/9/981.full
Herpes virus, organelle virus, triggers IgG1 and IgG3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC271254/
strep a visible bacteria : IgG1, IgG2a, IgG2b
https://www.ncbi.nlm.nih.gov/pubmed/15232177
IgG2c against amyloid (self protein outside of the cell)
https://www.ncbi.nlm.nih.gov/pubmed/12565127
IgG2c against tumors
http://www.jimmunol.org/content/jimmunol/172/2/929.full.pdf
IgG2c does not activate complement
https://www.researchgate.net/post/how_different_are_the_functions_of_IgG2a_and_IgG2c
https://www.sciencedirect.com/science/article/pii/S1877282X15000089
HPV, organelle (nucleus) virus, triggers IgG1 and IgG3
https://www.ncbi.nlm.nih.gov/pubmed/24058629
antibody review
http://absoluteantibody.com/antibody-resources/antibody-overview/antibody-isotypes-subtypes/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897107/
IgG4 inhibits compliment
https://www.sciencedirect.com/science/article/pii/B9780323069472100094
IgG2 triggers complement
IgG4 and IgG2 have the same non classical disulfide bond structure
https://www.researchgate.net/publication/221825860_Disulfide_bond_structures_of_IgG_molecules
Disulfide bonds in IgG
IgG1 has 2
IgG2 has 4
IgG3 has 11
why does IgG3 have 11 disulfide bonds? is it because it interacts with DNA?
DNA and disulfide bonds
https://www.sciencedirect.com/science/article/pii/S0014579399000599
IgG3 and anti-DNA
https://books.google.com/books?id=tj9JR3IITy8C&pg=PA455&lpg=PA455&dq=IgG3+anti+DNA&source=bl&ots=nnbaHQAhrL&sig=P7Vin_57g7Wqt1QwZZ4C4WNbqrc&hl=en&sa=X&ved=0ahUKEwjt4rO7hYPZAhUG02MKHVzPCmY4ChDoAQg2MAM#v=onepage&q=IgG3%20anti%20DNA&f=false
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