Cytokines
il-4 is a gamma chain cytokine responsible for triggering B cells and T helper cells
il-6 is a GP130 cytokine which increases neutrophils and macrophages
il-8 is also known as the neutrophil chemotactic factor
il-2 is a gamma cytokine triggering T cytotoxic cells (viral infections)
il-1 family cytokines trigger cells to cytokine rain. This produces massive amounts of chemokines. (attractants)
il-1 also induces the expression of adhesion proteins so the arriving immune system knows where to stick.
il-1 with il-23 at th17 causes them to secrete il-8 which calls the neutrophils
il-22 seems linked to cytosolic bacteria infections and the initiation of Th17
il-23 seem linked to bacterias that move into vacuoles
il-24 seems linked to golgi bacterias
il-26 is a PORE which helps break things down, second popping involving organelles etc.
type 1
Babies born with autism were the result of an autoimmune cross-targeting of the flu and mycoplasmas on the frontal lobe.
key cytokines: IFN gamma and il-4 Because the ER is infected by mycoplasmas, the mother had RA
http://cmr.asm.org/content/17/4/697.full
type 2: Cerebellum Autism: sutterella and the measles vaccine
(is this the regressive form?)
Key cytokine: il-23 because sutterella moves into vacuoles
type 3: temporal lobe autism: HHV6/CMV and tetanus
Key cytokine: IFNalpha a because the herpes viruses involved move into the nucleus
(causes deafness and high pain tolerance?)
measured levels of cytokines comparison of no-regression and regression autism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991432/table/T2/
neonatal autism cytokine profiles: High il-4
https://www.ncbi.nlm.nih.gov/pubmed/26392128
suggesting an infection is present in the newborns
postmortem autism il-6
https://www.ncbi.nlm.nih.gov/pubmed/23994594
https://vaccinepapers.org/wp-content/uploads/Brain-IL-6-and-autism.pdf
il-17a and severe autism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410815/
https://www.ncbi.nlm.nih.gov/pubmed/28455196
Hypotheses: 3 types of autism: frontal lobe, temporal lobe, and cerebellum
type 1
Babies born with autism were the result of an autoimmune cross-targeting of the flu and mycoplasmas on the frontal lobe.
il-4 levels are high in neonatal autism supporting the notion that an infection is present.
il-8 and newborns with autism?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080514/
il-8 and mycoplasmas
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146377
il-17a and mycoplasmas
https://www.nature.com/articles/s41598-017-13292-5
TH17 cells are called for a second popping when infections hide inside of cells' organelles
????? Are mycoplasmas so small they are treated like viruses?
mycoplasmas move into cells and nest into the endoplasmic reticulum which should trigger IFN gamma
IFN gamma is higher in mothers of autistic babies in the second trimester
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554862/
Mycoplasmas are linked to RA which is why I started with them.
Autism babies and mothers with RA: possible increased risk
https://www.ncbi.nlm.nih.gov/pubmed/28319657
http://jaacap.org/article/S0890-8567(17)31766-5/fulltext
What about the TNF alpha?
TNF-alpha and autism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669898/
TNF-alpha means that macrophages or dendritic cells or B cells are themselves infected
Is the flu infecting the immune system of autistic children? Previous blog matched the flu viruses up with dopamine receptors.
dopamine receptors on B cells and RA
https://www.ncbi.nlm.nih.gov/pubmed/25468566
flu shot triggering RA
https://www.hindawi.com/journals/crirh/2012/785028/
Flu virus uses dopamine receptors and the piece of the virus that binds the receptor is still there in the vaccine. The flu is a cytosolic virus. So pieces would go the receptor only to float around in the cytosol.
flu infects NK cells
http://jvi.asm.org/content/83/18/9215.full
dopamine receptors modulate NK cells
https://www.ncbi.nlm.nih.gov/pubmed/23799052
type 2: Cerebellum Autism: sutterella and the measles vaccine
(is this the regressive form?)
Key cytokine: il-23
il-23 and autism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038352/
il-23 could be linked to infections hiding in vacuoles
sutterella does move into vacuoles
But sutterella should be part of the regressive form of autism? regressive appeared to have normal il-23 compared to low il-23 in early onset.
campylobactera (which is similar to sutterella ) and it's cytokines: il-23
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936335/
ASD autism spectrum disorder and il-8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991432/
il-8 and thyroid stimulating hormone in autism
https://www.ncbi.nlm.nih.gov/pubmed/28577577
sutterella wadsworthensis and il-8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080374/
measle virus pieces could possible move into cells and attach to the ER
measles were identified in ER by electron microscope images
https://www.researchgate.net/publication/278787836_Histopathology_of_Measles_Report_of_2_Cases_With_New_Findings
So would the vaccine pieces trigger any cytokines?
measles vaccine and cytokines : il-2
https://www.ncbi.nlm.nih.gov/pubmed/12922130
il-2 is a gamma cytokine triggering Tcells (which makes sense because the body thinks a virus is there)
measles vaccine and IFNgamma
https://www.ncbi.nlm.nih.gov/pubmed/9285547
IFN gamma matches up with the ER
type 3: temporal lobe autism: HHV6/CMV and tetanus
Key cytokine: IFNalpha a
previous post
http://angelabiggs.blogspot.com/2015/04/roseola-6th-disease-and-autoimmune.html
it is not proven that HHV6 causes this form of autism and I am still questioning it myself
I just highly suspect that these kids with HHV6 got their vaccine while still sick.
temporal lobe autism group and seizures
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820486/
temporal lobe and HHV6
https://www.ncbi.nlm.nih.gov/pubmed/26933580
https://www.ncbi.nlm.nih.gov/pubmed/17535102
https://www.ncbi.nlm.nih.gov/pubmed/8012736
CMV and autism
https://www.ncbi.nlm.nih.gov/pubmed/17974154
CMV and seizures
https://www.ncbi.nlm.nih.gov/pubmed/18215482
CMV and infant seizures
https://www.ncbi.nlm.nih.gov/pubmed/17718825
HHV6 and seizures
https://hhv-6foundation.org/associated-conditions/hhv-6-seizures
does prenatal exposures of il-6 cause seizures?
https://www.ncbi.nlm.nih.gov/pubmed/26103532
after a seizure il-6 rapidly increases
http://www.sciencedirect.com/science/article/pii/S1059131110003122
HHV6 and lowers il-6 ?
https://hhv-6foundation.org/hiv-aids-progression/hhv-6-shedding-correlates-negatively-with-il-6-and-other-inflammatory-cytokines-in-hiv-patients
Beta-herpes viruses: CMV, HHV6, HHV7 : Estrogen-related receptors (CMV binding confirmed)
HHV6 TLR9
https://www.hindawi.com/journals/isrn/2013/834890/
HHV6 and CMV infect the nucleus: IFNalpha
IFN alpha and autism?
https://link.springer.com/article/10.1007%2FBF02178169
IFN alpha can cause hearing loss
https://www.ncbi.nlm.nih.gov/pubmed/8561688
autism and hearing loss
https://www.ncbi.nlm.nih.gov/pubmed/10587881
autism and high pain tolerance/sensory issues
http://www.sciencedirect.com/science/article/pii/S0021755717307659
IFN alpha and pain tolerance
https://www.ncbi.nlm.nih.gov/pubmed/10676852
only 30 children tested for HHV6 antibodies...only half had autism and no correlation with autism was found for hhv6 or hhv8
http://iv.iiarjournals.org/content/27/6/843.full
is it CMV?
But I contest that this is a small percent of autism kids anyway and the odds of it showing up would not be likely...unless their autism kids happened to be of the hear loss kind
Confusion with il-23
Tetanus is a bacteria that would secrete a toxin and move into vacuoles which I have linked to il-23
il-23 is the early onset but not regressive ? (should be both?)
https://www.ncbi.nlm.nih.gov/pubmed/27688738
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038352/
DTap (with the tetanus) is given at 2 months of age
https://www.webmd.com/children/vaccines/tc/tetanus-topic-overview#1
Does Tetanus trigger il-23???
Early and late epilepsy in autism
"The most frequent type of epilepsy was temporal lobe epilepsy and West syndrome in the early-onset epilepsy group (42.9% and 33.3%, respectively) and temporal lobe epilepsy, frontal lobe epilepsy and other symptomatic generalized epilepsy in the late-onset epilepsy group (each 31.6%). "
https://www.omicsonline.org/open-access/early-and-lateonset-epilepsy-in-autism-high-rate-of-secondarily-generalized-seizures-2165-7890.1000130.php?aid=26012
il-4 is a gamma chain cytokine responsible for triggering B cells and T helper cells
il-6 is a GP130 cytokine which increases neutrophils and macrophages
il-8 is also known as the neutrophil chemotactic factor
il-2 is a gamma cytokine triggering T cytotoxic cells (viral infections)
il-1 family cytokines trigger cells to cytokine rain. This produces massive amounts of chemokines. (attractants)
il-1 also induces the expression of adhesion proteins so the arriving immune system knows where to stick.
Th17 (the second popping T helper cells) secrete il-17a (just means the infections are inside host cells not outside or the virus is in organelles)
il-1 with il-23 at th17 causes them to secrete il-8 which calls the neutrophils
il-22 seems linked to cytosolic bacteria infections and the initiation of Th17
il-23 seem linked to bacterias that move into vacuoles
il-24 seems linked to golgi bacterias
il-26 is a PORE which helps break things down, second popping involving organelles etc.
type 1
Babies born with autism were the result of an autoimmune cross-targeting of the flu and mycoplasmas on the frontal lobe.
key cytokines: IFN gamma and il-4 Because the ER is infected by mycoplasmas, the mother had RA
http://cmr.asm.org/content/17/4/697.full
type 2: Cerebellum Autism: sutterella and the measles vaccine
(is this the regressive form?)
Key cytokine: il-23 because sutterella moves into vacuoles
type 3: temporal lobe autism: HHV6/CMV and tetanus
Key cytokine: IFNalpha a because the herpes viruses involved move into the nucleus
(causes deafness and high pain tolerance?)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991432/table/T2/
neonatal autism cytokine profiles: High il-4
https://www.ncbi.nlm.nih.gov/pubmed/26392128
suggesting an infection is present in the newborns
postmortem autism il-6
https://www.ncbi.nlm.nih.gov/pubmed/23994594
https://vaccinepapers.org/wp-content/uploads/Brain-IL-6-and-autism.pdf
il-17a and severe autism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3410815/
https://www.ncbi.nlm.nih.gov/pubmed/28455196
Hypotheses: 3 types of autism: frontal lobe, temporal lobe, and cerebellum
type 1
Babies born with autism were the result of an autoimmune cross-targeting of the flu and mycoplasmas on the frontal lobe.
il-4 levels are high in neonatal autism supporting the notion that an infection is present.
il-8 and newborns with autism?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080514/
il-8 and mycoplasmas
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146377
il-17a and mycoplasmas
https://www.nature.com/articles/s41598-017-13292-5
TH17 cells are called for a second popping when infections hide inside of cells' organelles
????? Are mycoplasmas so small they are treated like viruses?
mycoplasmas move into cells and nest into the endoplasmic reticulum which should trigger IFN gamma
IFN gamma is higher in mothers of autistic babies in the second trimester
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554862/
Mycoplasmas are linked to RA which is why I started with them.
Autism babies and mothers with RA: possible increased risk
https://www.ncbi.nlm.nih.gov/pubmed/28319657
http://jaacap.org/article/S0890-8567(17)31766-5/fulltext
What about the TNF alpha?
TNF-alpha and autism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5669898/
TNF-alpha means that macrophages or dendritic cells or B cells are themselves infected
Is the flu infecting the immune system of autistic children? Previous blog matched the flu viruses up with dopamine receptors.
dopamine receptors on B cells and RA
https://www.ncbi.nlm.nih.gov/pubmed/25468566
flu shot triggering RA
https://www.hindawi.com/journals/crirh/2012/785028/
Flu virus uses dopamine receptors and the piece of the virus that binds the receptor is still there in the vaccine. The flu is a cytosolic virus. So pieces would go the receptor only to float around in the cytosol.
flu infects NK cells
http://jvi.asm.org/content/83/18/9215.full
dopamine receptors modulate NK cells
https://www.ncbi.nlm.nih.gov/pubmed/23799052
type 2: Cerebellum Autism: sutterella and the measles vaccine
(is this the regressive form?)
Key cytokine: il-23
il-23 and autism
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038352/
il-23 could be linked to infections hiding in vacuoles
sutterella does move into vacuoles
But sutterella should be part of the regressive form of autism? regressive appeared to have normal il-23 compared to low il-23 in early onset.
campylobactera (which is similar to sutterella ) and it's cytokines: il-23
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936335/
ASD autism spectrum disorder and il-8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2991432/
il-8 and thyroid stimulating hormone in autism
https://www.ncbi.nlm.nih.gov/pubmed/28577577
sutterella wadsworthensis and il-8
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080374/
measle virus pieces could possible move into cells and attach to the ER
measles were identified in ER by electron microscope images
https://www.researchgate.net/publication/278787836_Histopathology_of_Measles_Report_of_2_Cases_With_New_Findings
So would the vaccine pieces trigger any cytokines?
measles vaccine and cytokines : il-2
https://www.ncbi.nlm.nih.gov/pubmed/12922130
il-2 is a gamma cytokine triggering Tcells (which makes sense because the body thinks a virus is there)
measles vaccine and IFNgamma
https://www.ncbi.nlm.nih.gov/pubmed/9285547
IFN gamma matches up with the ER
type 3: temporal lobe autism: HHV6/CMV and tetanus
Key cytokine: IFNalpha a
previous post
http://angelabiggs.blogspot.com/2015/04/roseola-6th-disease-and-autoimmune.html
it is not proven that HHV6 causes this form of autism and I am still questioning it myself
I just highly suspect that these kids with HHV6 got their vaccine while still sick.
temporal lobe autism group and seizures
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4820486/
temporal lobe and HHV6
https://www.ncbi.nlm.nih.gov/pubmed/26933580
https://www.ncbi.nlm.nih.gov/pubmed/17535102
https://www.ncbi.nlm.nih.gov/pubmed/8012736
CMV and autism
https://www.ncbi.nlm.nih.gov/pubmed/17974154
CMV and seizures
https://www.ncbi.nlm.nih.gov/pubmed/18215482
CMV and infant seizures
https://www.ncbi.nlm.nih.gov/pubmed/17718825
HHV6 and seizures
https://hhv-6foundation.org/associated-conditions/hhv-6-seizures
does prenatal exposures of il-6 cause seizures?
https://www.ncbi.nlm.nih.gov/pubmed/26103532
after a seizure il-6 rapidly increases
http://www.sciencedirect.com/science/article/pii/S1059131110003122
HHV6 and lowers il-6 ?
https://hhv-6foundation.org/hiv-aids-progression/hhv-6-shedding-correlates-negatively-with-il-6-and-other-inflammatory-cytokines-in-hiv-patients
Beta-herpes viruses: CMV, HHV6, HHV7 : Estrogen-related receptors (CMV binding confirmed)
HHV6 TLR9
https://www.hindawi.com/journals/isrn/2013/834890/
HHV6 and CMV infect the nucleus: IFNalpha
IFN alpha and autism?
https://link.springer.com/article/10.1007%2FBF02178169
IFN alpha can cause hearing loss
https://www.ncbi.nlm.nih.gov/pubmed/8561688
autism and hearing loss
https://www.ncbi.nlm.nih.gov/pubmed/10587881
autism and high pain tolerance/sensory issues
http://www.sciencedirect.com/science/article/pii/S0021755717307659
IFN alpha and pain tolerance
https://www.ncbi.nlm.nih.gov/pubmed/10676852
only 30 children tested for HHV6 antibodies...only half had autism and no correlation with autism was found for hhv6 or hhv8
http://iv.iiarjournals.org/content/27/6/843.full
is it CMV?
But I contest that this is a small percent of autism kids anyway and the odds of it showing up would not be likely...unless their autism kids happened to be of the hear loss kind
Confusion with il-23
Tetanus is a bacteria that would secrete a toxin and move into vacuoles which I have linked to il-23
il-23 is the early onset but not regressive ? (should be both?)
https://www.ncbi.nlm.nih.gov/pubmed/27688738
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5038352/
DTap (with the tetanus) is given at 2 months of age
https://www.webmd.com/children/vaccines/tc/tetanus-topic-overview#1
Does Tetanus trigger il-23???
Early and late epilepsy in autism
"The most frequent type of epilepsy was temporal lobe epilepsy and West syndrome in the early-onset epilepsy group (42.9% and 33.3%, respectively) and temporal lobe epilepsy, frontal lobe epilepsy and other symptomatic generalized epilepsy in the late-onset epilepsy group (each 31.6%). "
https://www.omicsonline.org/open-access/early-and-lateonset-epilepsy-in-autism-high-rate-of-secondarily-generalized-seizures-2165-7890.1000130.php?aid=26012
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