Monday, January 22, 2018

IFN cytokines and pore cytokines ?

IFNbeta and IFN alpha cause monocytes to infiltrate into tissue
https://www.ncbi.nlm.nih.gov/pubmed/12044977

IFN beta

IFN beta and the cytosol infections
https://www.ncbi.nlm.nih.gov/pubmed/18771559

IFN alpha (the nucleus and the mitochondria)

IFN alpha 2B
https://www.ncbi.nlm.nih.gov/pubmed/11426550

Is IFNalphaA the mitochondria while IFNalphaB the nucleus?

IFNalphaA induces apoptosis by the mitochondria
https://www.ncbi.nlm.nih.gov/pubmed/11850845
http://europepmc.org/abstract/med/17158029

IFNalpha2B has been shown to call cancer remission
https://www.hindawi.com/journals/scientifica/2014/970315/

IFNalpha2B and behcet (a nucleus disorder)
http://europepmc.org/abstract/med/7932420
https://www.ncbi.nlm.nih.gov/pubmed/22541781

IFN gamma

IFNgamma....tends to be made more by natural killer cells.  TLR8 which when triggered makes IFNgamma often never gets through.  This is the condition of a viral or foreign infection of the endoplasmic reticulum which means the HLAs may never make it to the surface.

IFN lambda

Is IFN lambda the golgi and is set off by poxvirus????
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4424062/

IFN lambda is in the family of il-19
https://www.ncbi.nlm.nih.gov/pubmed/17027511

IFN lambda 1,2,3 suppresses TH2 and pushes fight against viral infection
http://www.jimmunol.org/content/178/1_Supplement/S180.5
http://www.bloodjournal.org/content/113/23/5829?sso-checked=true

influenza A and IFN lambda
https://www.ncbi.nlm.nih.gov/pubmed/18787692

influenza and the golgi
http://onlinelibrary.wiley.com/store/10.1016/0014-5793(89)80668-4/asset/feb20014579389806684.pdf?v=1&t=ja44i6aj&s=23d27958562f6e827b09e685bbc6c08206fdcab6

il-20 and lfn-lamda have short hydrophobic regions and il-24 uses the il-20 receptor....are these all golgi cytokines?


The pore cytokines: il-19, il-22, il-26

il-19 and il-22 have long hydrophobic regions similar to il-26 which is a pore forming cytokine
Are these for fighting infections? Are they pore forming for the nucleus and the mitochondria (il-19) while il-26 pops the plasma membrane? Hypothesis...unclear

il-26 pore: against bacteria and our own cells
http://www.the-rheumatologist.org/article/il-26-plays-antimicrobial-role-in-immune-response/


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