Saturday, October 7, 2017

Yellow fever and TCR signaling

Only yellow fever altered TCR signaling
https://www.ncbi.nlm.nih.gov/pubmed/28968905

Is this because Yellow fever uses the MCR4 receptor?

I have been dividing up the flaviviruses with the melanocortin receptor they could use:

mcr1   Tick borne encephalitis virus/ hepatitis C   (Thrombocytopenia due to red blood cells with mcr1)

mcr2 (ACTH receptor)   Zika (placenta, developing brain)

mcr3  West nile (kidneys)

mcr3 and mcr1  Japanese encephalitis

mcr4  Yellow fever (liver)/ hepatitis C
                        
mcr5  Dengue (immune system T cells)

alpha MSH and T cells
https://www.ncbi.nlm.nih.gov/pubmed/10985666

MCR4: binds alpha MSH
https://en.wikipedia.org/wiki/Melanocortin_4_receptor

Liver and MCR4
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3312751/


No comments:

Post a Comment