One of the genes linked to breast cancer and ovarian cancer is the BRCA gene. Inheriting this gene mutated increases the chances of breast cancer but spontaneous breast cancer does not have it mutated. So it is not required for cancer.
BRCA makes a protein that repairs DNA. So this gene when mutated or inhibited by methylation the dividing cancer cells have increasingly more mutations.
BRCA hypermethylation and silencing prevented by resveratrol
https://www.ncbi.nlm.nih.gov/pubmed/22197621
BRCA hypermethylation found in cancers
https://www.ncbi.nlm.nih.gov/pubmed/24889916
So what is happening? When a cell has been set on a course to divide rapidly errors occur. Normally the BRCA would repair them during this process but if it is mutated or hypermethylated it doesn't work.
Looking at the viruses that may be involved in breast cancer risk:
HPV uses the cannabinoid receptor ( CB1 use by HPV is hypothesized on my blog on another post)
The cannabinoid receptor prevents the inhibitory effect of BRCA. Therefore if this receptor pathway was magnified then it could look as though BRCA was lost.
CMV/EBV use the estrogen alpha and estrogen like receptors which would methylate the gene and turn it off.
Triple negative breast cancers and BRCA
https://www.bcrf.org/blog/most-patients-triple-negative-breast-cancer-would-benefit-genetic-testing
BRCA mutation and triple negative breast cancer
https://www.ncbi.nlm.nih.gov/pubmed/28164176
Triple negative breast cancer and HPV
http://arizona.openrepository.com/arizona/handle/10150/623542
Ovarian cancer and hypermethylation of BRCA
https://www.ncbi.nlm.nih.gov/pubmed/24889916
Herpes virus mRNA and ovarian cancer
http://www.ncbi.nlm.nih.gov/pubmed/25485872
are ovarian cysts caused by the herpes virus?
Ovarian cysts are a risk for ovarian cancer
http://www.aafp.org/afp/2009/0915/p609.html
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