Thursday, October 1, 2015

Testicular cancer and Co-carcinogenesis

Francis Peyton Rous' Co-carcinogenesis hypothesis: that a virus and a carcinogen together cause cancer. (1966 nobel prize)

What I surmise from his hypothesis:

A virus enters a cell through a receptor, opens up and alters host DNA telomeres. The carcinogen with a benzene ring inhibits the virus' polymerase because viral polymerases have stronger binding affinities than the host's.

Cancer cells can make unlimited copies because of the telomere modifications.

Testicular cancer can be linked to herpes simplex 2. (herpes appears to use estrogen receptors)

Estrogen seems to stimulate testicular cancer
http://www.ncbi.nlm.nih.gov/pubmed/14555521

Herpes simplex 2 found in testicular cancer patients
http://www.ncbi.nlm.nih.gov/pubmed/8397088

Is prostate and testicular cancer linked?
http://www.asco.org/press-center/men-who-have-had-testicular-cancer-are-more-likely-develop-prostate-cancer-although

One form of prostate cancer is triggered by herpes 2.

Herpes virus 2 and prostate cancer
http://www.practiceupdate.com/content/genital-herpes-may-double-prostate-cancer-risk/13075

Estrogen receptors and prostate cancer (assuming herpes uses estrogen)
http://onlinelibrary.wiley.com/doi/10.1002/pros.10242/abstract

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