Several autoimmune diseases have gluten sensitivity: celiac, autism, schizophrenia, crohn's, and pandas. All of these diseases have culprits associated with them that cross the intestinal barrier and the blood brain barrier. The endothelial cells of the blood brain barrier and the epithelial cells of the intestine have stronger tight junctions than normal. The tight junctions proteins called claudin exist all over the body but the one with the lowest permability is the claudin 5 protein which is expressed in both of these areas.
This blog is an attempt to show that when these specific infections cross the barriers they destroy the barrier.
The gluten molecule is considered a macromolecule which is a large molecule.
http://www.ncbi.nlm.nih.gov/pubmed/17008153
The only way this molecule could get through the intestinal barrier would be if the tight junctions between cells were destroyed.
First how are the 2 barriers similar?
The epithelial intestinal barrier
http://www.ncbi.nlm.nih.gov/pubmed/19560575
The endothelial Blood brain barrier
http://www.ncbi.nlm.nih.gov/pubmed/12529927
https://books.google.com/books?id=vuDmnql7ensC&pg=PA315&lpg=PA315&dq=rhein+tight+junctions&source=bl&ots=VsBNlaQOlV&sig=Xa0O8_7OJfA2RniJ-QZIf1CuxFs&hl=en&sa=X&ei=T0n3VMTGDIyOyAT-4YCwBQ&ved=0CFAQ6AEwCQ#v=onepage&q=rhein%20tight%20junctions&f=false
What are tight junctions?
http://en.wikipedia.org/wiki/Tight_junction
what is Zonulin?
a protein that adjusts the permability of the tight junctions so that macromolecules can cross
http://www.ncbi.nlm.nih.gov/pubmed/21248165
http://en.wikipedia.org/wiki/Zonulin
They insinuate that gluten triggers this protein but this can't be the case. Everyone who eats gluten isn't gluten sensitive.
Rhein repairs tight junctions by increasing the expression of proteins...is claudin 5 one of them?
http://www.ncbi.nlm.nih.gov/pubmed/23864776
Rhein is from the rhubarb plant
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710415/
The infections:
Mycobacteria alters tight junctions
http://www.ncbi.nlm.nih.gov/pubmed/23940208
t.gondii then alters the tight junctions from inside the endothelial cells
http://www.ncbi.nlm.nih.gov/pubmed/22731726
t.gondii and gluten
https://www.ncbi.nlm.nih.gov/pubmed/23209841
Candida appears to infect like t.gondii by entering the host cells then altering the tight junctions
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC98530/
strep attaches to the cell then invades the endothelial cells of the BBB
http://jem.rupress.org/content/206/9/1835.2.full
http://www.ncbi.nlm.nih.gov/pubmed/23874613
strep infected epithelial cells down regulates claudins of the tight junctions
http://www.pubfacts.com/detail/21575911/Invasive-bacterial-pathogens-exploit-TLR-mediated-downregulation-of-tight-junction-components-to-fac
Strep and gluten
https://www.ncbi.nlm.nih.gov/pubmed/15814071
Sutterella is an off shoot of campylobacteria which alters tight junctions (lowers claudin 5)
https://microbewiki.kenyon.edu/index.php/Sutterella_wadsworthensis
http://www.oalib.com/paper/115076#.VPeDyPnF-So
e.coli and gluten
https://www.ncbi.nlm.nih.gov/pubmed/26456581
e.coli disrupts the tight junctions....how does claudin 5 fit?
http://iai.asm.org/content/69/9/5679
e.coli toxin alters claudin 1..does the toxin disrupt claudin 5?
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113273
Claudins are the components of the tight junctions (the proteins that make up the tight junction)
http://en.wikipedia.org/wiki/Claudin
http://physrev.physiology.org/content/93/2/525
Caudin 5 and the BBB's endothelial cells
http://www.ncbi.nlm.nih.gov/pubmed/12743096
http://www.ncbi.nlm.nih.gov/pubmed/25470344
Claudin 5 and the epithelial intestinal cells
http://www.ncbi.nlm.nih.gov/pubmed/20583258
specifically in the small intestine's crypt ad lower villus (crypt is the intestinal gland that secretes the intestinal juices) in otherwords claudin 5 is expressed in an area where the most absorption occurs)
distribution of claudins in the intestine
http://www.ncbi.nlm.nih.gov/pubmed/25153024
Claudin 5 and 10 uniform distribution at crypt and surface epithelial which means like at the BBB claudin 5 is blocking and protecting. Food is absorbed only through the intestinal villus not between the cells.
This blog is an attempt to show that when these specific infections cross the barriers they destroy the barrier.
The gluten molecule is considered a macromolecule which is a large molecule.
http://www.ncbi.nlm.nih.gov/pubmed/17008153
The only way this molecule could get through the intestinal barrier would be if the tight junctions between cells were destroyed.
First how are the 2 barriers similar?
The epithelial intestinal barrier
http://www.ncbi.nlm.nih.gov/pubmed/19560575
The endothelial Blood brain barrier
http://www.ncbi.nlm.nih.gov/pubmed/12529927
https://books.google.com/books?id=vuDmnql7ensC&pg=PA315&lpg=PA315&dq=rhein+tight+junctions&source=bl&ots=VsBNlaQOlV&sig=Xa0O8_7OJfA2RniJ-QZIf1CuxFs&hl=en&sa=X&ei=T0n3VMTGDIyOyAT-4YCwBQ&ved=0CFAQ6AEwCQ#v=onepage&q=rhein%20tight%20junctions&f=false
What are tight junctions?
http://en.wikipedia.org/wiki/Tight_junction
what is Zonulin?
a protein that adjusts the permability of the tight junctions so that macromolecules can cross
http://www.ncbi.nlm.nih.gov/pubmed/21248165
http://en.wikipedia.org/wiki/Zonulin
They insinuate that gluten triggers this protein but this can't be the case. Everyone who eats gluten isn't gluten sensitive.
Rhein repairs tight junctions by increasing the expression of proteins...is claudin 5 one of them?
http://www.ncbi.nlm.nih.gov/pubmed/23864776
Rhein is from the rhubarb plant
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3710415/
The infections:
Mycobacteria alters tight junctions
http://www.ncbi.nlm.nih.gov/pubmed/23940208
t.gondii then alters the tight junctions from inside the endothelial cells
http://www.ncbi.nlm.nih.gov/pubmed/22731726
t.gondii and gluten
https://www.ncbi.nlm.nih.gov/pubmed/23209841
Candida appears to infect like t.gondii by entering the host cells then altering the tight junctions
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC98530/
strep attaches to the cell then invades the endothelial cells of the BBB
http://jem.rupress.org/content/206/9/1835.2.full
http://www.ncbi.nlm.nih.gov/pubmed/23874613
strep infected epithelial cells down regulates claudins of the tight junctions
http://www.pubfacts.com/detail/21575911/Invasive-bacterial-pathogens-exploit-TLR-mediated-downregulation-of-tight-junction-components-to-fac
Strep and gluten
https://www.ncbi.nlm.nih.gov/pubmed/15814071
Sutterella is an off shoot of campylobacteria which alters tight junctions (lowers claudin 5)
https://microbewiki.kenyon.edu/index.php/Sutterella_wadsworthensis
http://www.oalib.com/paper/115076#.VPeDyPnF-So
e.coli and gluten
https://www.ncbi.nlm.nih.gov/pubmed/26456581
e.coli disrupts the tight junctions....how does claudin 5 fit?
http://iai.asm.org/content/69/9/5679
e.coli toxin alters claudin 1..does the toxin disrupt claudin 5?
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113273
Claudins are the components of the tight junctions (the proteins that make up the tight junction)
http://en.wikipedia.org/wiki/Claudin
http://physrev.physiology.org/content/93/2/525
Caudin 5 and the BBB's endothelial cells
http://www.ncbi.nlm.nih.gov/pubmed/12743096
http://www.ncbi.nlm.nih.gov/pubmed/25470344
Claudin 5 and the epithelial intestinal cells
http://www.ncbi.nlm.nih.gov/pubmed/20583258
specifically in the small intestine's crypt ad lower villus (crypt is the intestinal gland that secretes the intestinal juices) in otherwords claudin 5 is expressed in an area where the most absorption occurs)
distribution of claudins in the intestine
http://www.ncbi.nlm.nih.gov/pubmed/25153024
Claudin 5 and 10 uniform distribution at crypt and surface epithelial which means like at the BBB claudin 5 is blocking and protecting. Food is absorbed only through the intestinal villus not between the cells.
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