HLA-DR and HLA-DQ connections to non viral infections

95% of celiacs have hla-dq2...is this E.coli binding issues?

Hla are Tcell mailboxes which present what is inside. The DQ and DR group is found on antigen presenting cells like macrophages which consume and breakdown pathogens.

The streptococcal super antigen is presented by the hla-DQ rather than the hla-DR
http://www.nature.com/nsmb/journal/v6/n2/full/nsb0299_123.html

In the case of celiacs the infection appears to be E.coli which means that the hla-dq2 may not very good at binding antigens from these.

Other autoimmune diseases related to celiac disease like some type one diabetes and autoimmune liver disease also have the hla-dq issue
http://www.ncbi.nlm.nih.gov/pubmed/18339073
http://www.ncbi.nlm.nih.gov/pubmed/21912932

mycoplasmas have 10% the cell volume of e.coli making them even smaller

HLA-dq8  is this mycoplasmas?

hla-dq8 with type one diabetes with RA
http://en.wikipedia.org/wiki/HLA-DQ8

Does the hla-dq generally bind the infections smaller than 2micrometers long? while the larger infections are hla-dr? e.coli is 2 micrometers and strep is 2 micrometers while a mycobacteria can be 8 micrometers.

Hla-dr is this Fungal infections?

hashimoto's thyroid and hla-dr
http://www.ncbi.nlm.nih.gov/pubmed/1676351
http://www.ncbi.nlm.nih.gov/pubmed/3472422

sjogren's and hla-drb1
http://www.ncbi.nlm.nih.gov/pubmed/9598888

Hla-drb7 is this Klebsiella?

Ankylosing spondylitis and hla-drb7

Hla-Dr and mycobacteria?

psoriasis and hla-dr
http://www.ncbi.nlm.nih.gov/pubmed/6173446

parkinson's and hla-dr
http://www.ncbi.nlm.nih.gov/pubmed/22807207
http://www.ncbi.nlm.nih.gov/pubmed/25319953

HlA-DRB1 with multiple sclerosis
http://ghr.nlm.nih.gov/condition/multiple-sclerosis
http://www.ncbi.nlm.nih.gov/pubmed/23485854