Wednesday, March 25, 2015

Estrogen and autoimmune disease

 Lupus, and sjogren's appears more often in women than men.  Is it because estrogen effects one of the infections involved?

Estrogen and dimorphic switching of fungal infections. Fungal infections switch between mold and yeast forms. Estrogen has been known to favor the mold state.

The autoimmune diseases that we have associated with fungal infections are also those associated with Hoshiomto's thyroid.  All of these should be sensitive to estrogen if the dimorphic switching is being occurring.

Sjogren's and Estrogen
http://www.ncbi.nlm.nih.gov/pubmed/25682089
http://www.ncbi.nlm.nih.gov/pubmed/24567374 (estrogen receptor)

Asperger's and Estrogen
http://sfari.org/news-and-opinion/in-brief/2012/cognition-and-behavior-asperger-brains-similar-across-sexes

Vitiligo and Estrogen
http://www.ncbi.nlm.nih.gov/pubmed/15381239 (estrogen receptor)

Microscopic colitis
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3795533

RA tends to occur more often in woman too. Is that because the mycoplasmas do better in high estrogen environments ?

Some mycoplasmas depend on estrogen for growth others progesterone.
http://www.ncbi.nlm.nih.gov/pubmed/8471540

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